Results 111 to 120 of about 1,080,879 (306)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Pharmaceutical Activities of Theanine: A Phytochemical Nutrient
Food Science & NutritionABSTRACT Theanine, first isolated from tea ( Camellia sinensis (L.) O. Kuntze), has been recognized for its multiple pharmaceutical functions. Typically, theanine is known for its protective effect on neural disorders.
Xuelan Chong, Jian Hou, Hua‐Feng He
openaire +2 more sources
Reducing Unlawful Prescription Drug Promotion: Is the Public Health Being Served by an Enforcement Approach that Focuses on Punishment? [PDF]
, 2012 Despite the imposition of increasingly substantial fines and recently successful efforts to impose individual liability on corporate executives under the Park doctrine, punishing pharmaceutical companies and their executives for unlawful promotional ...
Girard, Vicki W.
core +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
NonDpharmaceutical correction of intravascular platelet activity in hypertensive patients
Российский кардиологический журнал, 2005 Hypocaloric diet and individually tailored physical activity in patients with arterial hypertension and metabolic syndrome normalized lipid profile, intravascular platelet activity, and decreased peroxidation intensity.
I. N. Medvedev
doaj
Confronting the Ghost: Legal Strategies to Oust Medical Ghostwriters [PDF]
, 2017 Articles published in medical journals contribute significantly to public health by disseminating medical information to physicians, thereby influencing prescribing practices.
Minasi, Deanna
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
PHARMACEUTICAL LEGISLATION OR PHARMACEUTICAL LAW? ANALYSIS
Vitae, 2011 After legal enaltment in the pharmaceutical profession appear two intimately related concepts: the pharmaceutical law andt the pharmaceutical legislation that we should define and analyze.
Carlos del CASTILLO Rodríguez
doaj
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Coordinating on Lower Prices: Pharmaceutical Pricing Under Political Pressure [PDF]
This paper investigates possible effects of political activity on pharmaceutical prices, focusing on the health care reform period. We characterize firms based on their vulnerability to future price regulation and find that the more vulnerable firms were
Catherine Wolfram, Sara Fisher Ellison
core