Results 111 to 120 of about 4,080,009 (401)

Identifying High‐Impact Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus‐Based Approach

Arthritis Care &Research, Accepted Article.
Objective We conducted formative research aimed at identifying solutions that address inequitable health outcomes in lupus due to adverse social determinants of health. Methods We conducted a search for keywords which provided insights into potential solutions and initiatives underway. An advisory panel of lupus experts iteratively reviewed the list of
Joy Buie, Michael P. Fisher, Kristen Backor, Hannah Tyldsley, Ashira Blazer, Candace Feldman, Andrea Knight, S. Sam Lim, Barbara Ann Polk, Ed Yelin, Edith Williams, Karen H. Costenbader   +11 more
wiley   +1 more source

Scaffold hopping for discovery of N, N-dibenzylcinnamamide (DBCA) derivatives as novel allosteric GSK-3β inhibitors: Design, synthesis and anti-inflammatory evaluation

Results in Chemistry
Glycogen synthase kinase-3β (GSK-3β) has been identified to promote inflammation and its inhibitors have also been proven to treat some inflammatory-mediated diseases in animal models.
Xinyi Zhang, Weiwei Zhao, Feilong Wang, Wei Zhao, Liang Hu, Zhendong Xie, Xueyan Zhu, Peng Zhang, Yong Chu   +8 more
doaj   +1 more source

Enhancement of ascomycin production via a combination of atmospheric and room temperature plasma mutagenesis in Streptomyces hygroscopicus and medium optimization

AMB Express, 2019
Ascomycin, a key intermediate for chemical synthesis of immunosuppressive drug pimecrolimus, is produced by Streptomyces hygroscopicus var. ascomyceticus. In order to improve the strain production, the original S.
Zhituo Yu, Xiaofang Shen, Yuanjie Wu, Songbai Yang, Dianwen Ju, Shaoxin Chen   +5 more
doaj   +1 more source

Medicine and the Pharmaceutical Industry [PDF]

European Neurology, 2002
Accessible online at: www.karger.com/journals/ene Throughout Europe, institutions providing independent research on efficacy, safety and costs of drugs and therapies are on the retreat: research at universities is increasingly impaired by administrative burdens, lack of funding and staff demoralisation.
openaire   +3 more sources

Serum soluble mediator signatures of lupus nephritis: histological features and response to treatment

Arthritis Care &Research, Accepted Article.
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of histological features and treatment response.
Andrea Fava, Catriona A. Wagner, Carla J. Guthridge, Susan Macwana, Wade DeJager, Melissa E. Munroe, Peter Izmirly, H. Michael Belmont, Betty Diamond, Anne Davidson, Paul J. Utz, Michael H Weisman, Philip M Carlucci, Maria Dall'Era, Kenneth Kalunian, Chaim Putterman, Jennifer Anolik, Jennifer L Barnas, David Wofsy, Diane Kamen, Richard A Furie, Deepak A Rao, the Accelerating Medicines Partnership (AMP) RA/SLE Network, Michelle Petri, Joel M. Guthridge, Jill Buyon, Judith A. James   +26 more
wiley   +1 more source

IMPLEMENTATION MECHANISMS OF INNOVATIVE STRATEGIES IN PHARMACEUTICAL INDUSTRY AND KEY INVESTMENT PROJECTS

Статистика и экономика, 2016
In this article, the author reflects the strategic goals, principles and objectives of the pharmaceutical industry, the situation in the industry, the industry's problems, methods and ways of solving these problems.
Marko Jovanovich
doaj   +1 more source

What the doctor ordered? : the economics of drug reimportation [PDF]

Pharmaceutical industry ; Drugs ...
Aaron Steelman
core  

Biocatalysis in the Pharmaceutical Industry: The Need for Speed.

ACS Medicinal Chemistry Letters, 2017
The use of biocatalysis in the pharmaceutical industry continues to expand as a result of increased access to enzymes and the ability to engineer those enzymes to meet the demands of industrial processes. However, we are still just scratching the surface
M. Truppo
semanticscholar   +1 more source

Requirements and Evaluation of Commercial Digital Light Processing 3D Printers for Upscaled Production of Microstructured Tissue Culture Devices

Advanced Engineering Materials, EarlyView.
Commercial light‐based 3D printers increasingly find use for industry‐scale production of microstructured tissue culture devices. How can commercial printer performance be assessed for a given application? This work introduces simplified quantitative metrics based on microstructural fidelity analysis, addressing key manufacturing challenges in scaling ...
Zoltán András Guller, Freja Høier, Rujing Zhang, Sandra Wilson, Niels B. Larsen   +4 more
wiley   +1 more source

Longitudinal Study on the Performance of U.S. Pharmaceutical Firms: The Increasing Role of Marketing [PDF]

Nowadays, the U.S. pharmaceutical industry has been under thorough scrutiny. Popular press claims of intensive marketing activities that go beyond R&D, the strong increase of me-too drugs, and, at the same time, the high industry profitability have ...
Pattikawa, L.H.
core   +1 more source