Results 21 to 30 of about 537,841 (319)

Synthesis and Biological Evaluation of a Series of Novel 1-(3-((6-Fluoropyridin-3-yl)oxy)propyl)piperazines as Dopamine/Serotonin Receptor Agonists

open access: yesPharmaceutical Fronts, 2022
Evidence suggested that the use of partial dopamine D2/D3 receptor agonists may be a better choice for the treatment of Parkinson's disease (PD), and the stimulation of 5-HT1A receptors (mainly via nondopaminergic mechanisms) alleviates motor and ...
Xin-Li Du   +7 more
doaj   +1 more source

Extending Viability of Bifidobacterium longum in Chitosan-Coated Alginate Microcapsules Using Emulsification and Internal Gelation Encapsulation Technology

open access: yesFrontiers in Microbiology, 2019
Bifidobacteria are considered one of the most important intestinal probiotics because of their significant health impact. However, this ability is usually limited by gastrointestinal fluid and temperature sensitivity. Emulsification and internal gelation
Rui Ji   +13 more
doaj   +1 more source

Pharmacovigilance in the pharmaceutical industry [PDF]

open access: yesBritish Journal of Clinical Pharmacology, 1998
Pharmacovigilance has been defined as the process of identifying and responding to drug safety issues [1] and has grown considerably as a discipline over the past 10 to 15 years. An educational survey in 1994 revealed that more than 320 people currently worked in company pharmacovigilance functions in the UK alone [2].
J. C. C. Talbot, B. S. Nilsson
openaire   +3 more sources

The implications of WTO accession on the pharmaceutical industry in China [PDF]

open access: yes, 2002
Given the limited capabilities of R&D and global distribution channels, and the virtual non-existence of patented drugs, the Chinese pharmaceutical industry has little chance to enter the global market of Western prescription drugs and compete with the ...
Yeung, Godfrey
core   +1 more source

Identification, Characterization and Quantification of Process-Related and Degradation Impurities in Lisdexamfetamine Dimesylate: Identifiction of Two New Compounds

open access: yesMolecules, 2018
Twelve impurities (process-related and degradation) in lisdexamfetamine dimesylate (LDX), a central nervous system (CNS) stimulant drug, were first separated and quantified by high-performance liquid chromatography (HPLC) and then identified by liquid ...
Shenghua Gao   +5 more
doaj   +1 more source

Design, Synthesis, and Evaluation of Benzoheterocyclic-Containing Derivatives as Novel HDAC1 Inhibitors

open access: yesPharmaceutical Fronts, 2022
In this study, the synthesis and biological evaluation of a variety of benzoheterocyclic-containing benzamide derivatives were described. Some of these compounds were proved to inhibiting the activity of histone deacetylase 1 (HDAC1) with IC50 values ...
Min-Ru Jiao   +5 more
doaj   +1 more source

Industry-scale application and evaluation of deep learning for drug target prediction [PDF]

open access: yes, 2019
Artificial intelligence (AI) is undergoing a revolution thanks to the breakthroughs of machine learning algorithms in computer vision, speech recognition, natural language processing and generative modelling.
Ashby, Thomas J.   +18 more
core   +1 more source

Assessment of the Utilization of Quadruped Robots in Pharmaceutical Research and Development Laboratories [PDF]

open access: yes, 2023
Drug development is becoming more and more complex and resource-intensive. To reduce the costs and the time-to-market, the pharmaceutical industry employs cutting-edge automation solutions. Supportive robotics technologies, such as stationary and mobile manipulators, exist in various laboratory settings.
arxiv   +1 more source

Synthesis and Characterization of Process-Related Impurities of Antidiabetic Drug Linagliptin

open access: yesMolecules, 2016
Linagliptin, a xanthine derivative, is a highly potent, selective, long-acting and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.
Yiwen Huang   +3 more
doaj   +1 more source

Pharmaceutical industry before COVID-19 [PDF]

open access: yesFarmacja Polska, 2020
The 2019 CPhI Annual Report describing rankings, innovations and key trends in pharma industry is summarized. Pharmaceutical markets were assessed based on an the following indicators: growth potential, API manufacturing, innovation, competitiveness and ...
Krzysztof Woyna-Orlewicz   +1 more
doaj   +1 more source

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