Results 41 to 50 of about 4,006,128 (388)

Industrial-Scale Preparation of a Key Intermediate for the Manufacture of Therapeutic SGLT2 Inhibitors

Pharmaceutical Fronts, 2022
(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-methyltetrahydro-2H-pyran-2-one (1) is a key intermediate for the preparation of promising SGLT2 inhibitors currently undergoing clinical tests for diabetes therapy.
Lei Huang, Yi Zhang, Xiao-Hui Shan, Yu Liu, Jian-Qi Li   +4 more
doaj   +1 more source

Raman Spectroscopy for Quantitative Analysis in the Pharmaceutical Industry.

Journal of Pharmacy & Pharmaceutical Sciences, 2020
Raman spectroscopy is a very promising technique increasingly used in the pharmaceutical industry. Due to its development and improved instrumental versatility achieved over recent decades and through the application of chemometric methods, this ...
J. D. Jesus, R. Löbenberg, N. Bou-Chacra   +2 more
semanticscholar   +1 more source

Improvement of Nemadectin Production by Overexpressing the Regulatory Gene nemR and Nemadectin Biosynthetic Gene Cluster in Streptomyces Cyaneogriseus

Pharmaceutical Fronts, 2020
Nemadectin, a 16-member macrocyclic lactone antiparasitic antibiotic, is produced by Streptomyces cyaneogriseus subspecies noncyanogenus. Moxidectin, a C-23 oximate derivative of nemadectin, is widely used as a pesticide due to its broad-spectrum, highly
Yuan-Jie Wu, Song-Bai Yang, Zheng-Yu Zhang, Shao-Xin Chen   +3 more
doaj   +1 more source

Design, Synthesis, and Antidepressant Activity Study of Novel Aryl Piperazines Targeting Both 5-HT1A and Sigma-1 Receptors

Pharmaceutical Fronts, 2021
A total of 20 novel aryl piperazine derivatives were designed and synthesized, and their structures were confirmed by mass spectrometry and nuclear magnetic resonance analyses. Their 5-HT1A and sigma-1 receptor affinities were determined, and six of them
Yan-Na Ni, Xin-Li Du, Tao Wang, Yuan-Yuan Chen, Xiang-Qing Xu, Song Zhao, Jian-Qi Li, Guan Wang   +7 more
doaj   +1 more source

Extending the in vivo Half-Life of Adalimumab Fab via Sortase A-Mediated Conjugation of Adalimumab Fab with Modified Fatty Acids

Pharmaceutical Fronts, 2020
Adalimumab, a full-length monoclonal antibody, is widely used as an anti-tumor necrosis factor-α (anti-TNF-α) agent. In this article, we aimed to prolong the in vivo half-life of adalimumab antigen-binding fragment (Fab) through Sortase A (SrtA)-mediated
Qing-Bin Zhang, Si-Da Ruan, Yong Wu, Jin-Hua Zhang, Jian-Guang Lu, Jun Feng   +5 more
doaj   +1 more source

Enantioselective aza-Michael Cyclization Reaction Catalyzed by Quinine-Derived Monoquaternary Ammonium Salts: an Effective Route to Synthesize Letermovir

Pharmaceutical Fronts, 2021
A series of mono- or bis-quaternary ammonium salts derived from cinchonidine or quinine was synthesized and screened as potent phase-transfer catalysts for the reaction of aza-Michael cyclization, the key step in the synthesis of letermovir.
Liang Chen, Wei-Yuan Liu, Si-Ju Bi, Ting Zhou, Jing Pan, Xun-Lei Lv, Kuai-Le Lin, Wei-Cheng Zhou   +7 more
doaj   +1 more source

An Overview of Progress in the International Regulation of the Pharmaceutical Industry [PDF]

, 2002
[Excerpt] “The pharmaceutical industry, a significant source of healthcare throughout the world, has several features that distinguish it from the rest of the health industry.
Burakoff, Aaron, Harvard University, Costa-Font, Joan   +1 more
core   +1 more source

A cross-sectional analysis of pharmaceutical industry-funded events for health professionals in Australia [PDF]

, 2017
Objectives: To analyse patterns and characteristics of pharmaceutical industry sponsorship of events for Australian health professionals and to understand the implications of recent changes in transparency provisions that no longer require reporting of ...
Bero, Lisa A, Fabbri, Alice, Grundy, Quinn, Mintzes, Barbara, Moynihan, Ray, Swandari, Swestika, Walkom, Emily   +6 more
core   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Development of a mitochondrial mini-barcode and its application in metabarcoding for identification of leech in traditional Chinese medicine

Scientific Reports
In Traditional Chinese Medicine (TCM), the medicinal leech is vital for treatments to promote blood circulation and eliminate blood stasis. However, the prevalence of counterfeit leech products in the market undermines the quality and efficacy of these ...
Chenfeng Shi, Yuhan Guo, Lijuan Yao, Yunhui Xu, Jing Zhou, Moli Hua   +5 more
doaj   +1 more source