Results 81 to 90 of about 537,841 (319)
Innovation in the pharmaceutical industry [PDF]
BMJ, 1994 The pharmaceutical industry today is operating in an environment whose main feature is an unprecedented pace of change. In most markets the rising costs of health care are of increasing concern, and the medicines bill is being targeted for savings. New constraints are limiting the medicines that can be used and paid for in the system.
openaire +3 more sources
Recurrent Neural Network-based Model Predictive Control for Continuous Pharmaceutical Manufacturing [PDF]
arXiv, 2018 The pharmaceutical industry has witnessed exponential growth in transforming operations towards continuous manufacturing to effectively achieve increased profitability, reduced waste, and extended product range. Model Predictive Control (MPC) can be applied for enabling this vision, in providing superior regulation of critical quality attributes.
arxiv
FEBS Open Bio, EarlyView.ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu +6 more
wiley +1 more source
Strategic Development Trends in the World Pharmaceutical Industry [PDF]
The main purpose of the paper is to research and evaluate the strategic development trends in the world pharmaceutical industry in the period 1996–2006.We aim to find that mergers and acquisitions prevail as a vital strategic development option in the ...
Dragan Kesic
core
Big Pharma, little science? A bibliometric perspective on big pharma's R&D decline [PDF]
, 2013 There is a widespread perception that pharmaceutical R&D is facing a productivity crisis characterised by stagnation in the numbers of new drug approvals in the face of increasing R&D costs. This study explores pharmaceutical R&D dynamics by examining the publication activities of all R&D laboratories of the major European and US pharmaceutical firms ...
arxiv +1 more source
FEBS Open Bio, EarlyView.Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu +4 more
wiley +1 more source
Molecules, 2018 ZL-004, a promising small molecule that increases white blood cell counts, was developed for extended-release nanosuspensions to improve low solubility and compliance of patients. In vivo pharmacokinetic studies of nanosuspensions with different particle
Chengyue Guo +6 more
doaj +1 more source
AMB Express, 2020 A82846B, producing by Kibdelosporangium aridum, is an important precursor of the semi-synthetic glycopeptide antibiotic Oritavancin. K. aridum produces three components A82846A, B and C, so it is essential to increase A82846B titer and reduce A82846A and
Xun Tian, He Huang, Hai-Feng Hu
doaj +1 more source
Economy of scales in R&D with block-busters [PDF]
Quantitative Finance 2, 224--227 (2002), 2000 Are large scale research programs that include many projects more productive than smaller ones with fewer projects? This problem of economy of scale is particularly relevant for understanding recent mergers in particular in the pharmaceutical industry. We present a quantitative theory based on the characterization of distributions of discounted sales S
arxiv
Advanced Biology, EarlyView.Positively supercharged mGreenLatern protein is self‐assembled electrostatically with negatively charged zinc phthalocyanines to yield bio‐based photoactive materials in aqueous media. The addition of phthalocyanines results in the formation of large complexes fully quenching of the protein fluorescence. The results indicate an energy transfer from the
Sharon Saarinen +10 more
wiley +1 more source