Results 51 to 60 of about 258,478 (322)

Critical Success Factors for Adopting Cloud Computing in the Pharmaceutical Manufacturing Companies [PDF]

open access: yesManagement and Economics Review, 2018
Cloud computing is a model for enabling ubiquitous, easy, and on-demand network access to a shared aggregation of configurable computing sources. Adopting of cloud computing in the pharmaceutical manufacturing is influenced by a group of critical success
Mohammad Saleem AL-SHURA   +3 more
doaj   +1 more source

Key problems of the foreign medicines contract production organization in developing countries

open access: yesRUDN Journal of Economics, 2023
Contract manufacturing is gaining momentum in the pharmaceutical industry. Many pharmaceutical companies that do not have enough time and financial resources to build a fullfledged drug development chain transfer some or all phases of development and ...
Sergey U. Chernikov   +2 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

Design of microfluidic networks [PDF]

open access: yes, 2005
Microfluidics is a relatively new and fast growing research area in fluid mechanics. The devices in question are thin wafers containing etched or printed interconnecting channels through which fluids are pumped, which can mix and/or react at various ...
Billingham, John   +3 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Manufacturing mass intensity: 15 ​Years of Process Mass Intensity and development of the metric into plant cleaning and beyond

open access: yesCurrent Research in Green and Sustainable Chemistry, 2022
The American Chemical Society Green Chemistry Institute (ACS GCI) Pharmaceutical Roundtable is committed to continue to expand and identify elements of small-molecule active pharmaceutical ingredient (API) manufacturing that should be quantified to drive
Colin H. Benison, Philippa R. Payne
doaj   +1 more source

Inventory drivers in a pharmaceutical supply chain [PDF]

open access: yes, 2017
In recent years, inventory reduction has been a key objective of pharmaceutical companies, especially within cost optimization initiatives. Pharmaceutical supply chains are characterized by volatile and unpredictable demands –especially in emergent ...
Masvidal Andreu, Clara
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Graph-theoretical optimization of the aspirin synthesis pathway: Enhancing green chemistry in pharmaceutical manufacturing

open access: yesComputational and Mathematical Biophysics
Aspirin, one of the most widely produced and consumed pharmaceuticals globally, presents an ideal case for exploring sustainable synthesis methods in pharmaceutical manufacturing.
Rooban Sanjai Shanmugavel Kannan   +1 more
doaj   +1 more source

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