Results 61 to 70 of about 2,713,900 (282)
Early detection of capping risk in pharmaceutical compacts [PDF]
, 2018 Capping is a common mechanical defect in tablet manufacturing, exhibited during or after the compression process. Predicting tablet capping in terms of process variables (e.g.
Cetinkaya, Centin +4 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Effect of moisture on solid state stability
Journal of Medical Science, 2023 Water is omnipresent during pharmaceutical product manufacturing and may interact with the drug substance, excipients, and the drug product in either solvent or vapor form, resulting in several physico-chemical changes, ultimately affecting product ...
Stanko Srčič, Zoran Lavrič
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms
Pharmaceutics, 2020 In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME).
Jaemin Lee +4 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Computational and Mathematical BiophysicsAspirin, one of the most widely produced and consumed pharmaceuticals globally, presents an ideal case for exploring sustainable synthesis methods in pharmaceutical manufacturing.
Rooban Sanjai Shanmugavel Kannan +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Critical Success Factors for Adopting Cloud Computing in the Pharmaceutical Manufacturing Companies [PDF]
Management and Economics Review, 2018 Cloud computing is a model for enabling ubiquitous, easy, and on-demand network access to a shared aggregation of configurable computing sources. Adopting of cloud computing in the pharmaceutical manufacturing is influenced by a group of critical success
Mohammad Saleem AL-SHURA +3 more
doaj +1 more source
Key problems of the foreign medicines contract production organization in developing countries
RUDN Journal of Economics, 2023 Contract manufacturing is gaining momentum in the pharmaceutical industry. Many pharmaceutical companies that do not have enough time and financial resources to build a fullfledged drug development chain transfer some or all phases of development and ...
Sergey U. Chernikov +2 more
doaj +1 more source