Results 61 to 70 of about 2,517,866 (353)

Recurrent Neural Network-based Model Predictive Control for Continuous Pharmaceutical Manufacturing [PDF]

Mathematics, 2018
The pharmaceutical industry has witnessed exponential growth in transforming operations towards continuous manufacturing to increase profitability, reduce waste and extend product ranges.
Wee Chin Wong, Jiali Li, Xiaonan Wang
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Critical Success Factors for Adopting Cloud Computing in the Pharmaceutical Manufacturing Companies [PDF]

Management and Economics Review, 2018
Cloud computing is a model for enabling ubiquitous, easy, and on-demand network access to a shared aggregation of configurable computing sources. Adopting of cloud computing in the pharmaceutical manufacturing is influenced by a group of critical success
Mohammad Saleem AL-SHURA, Abdelrahim M. ZABADI, Mohamad ABUGHAZALEH, Marwa A. ALHADI   +3 more
doaj   +1 more source

Key problems of the foreign medicines contract production organization in developing countries

RUDN Journal of Economics, 2023
Contract manufacturing is gaining momentum in the pharmaceutical industry. Many pharmaceutical companies that do not have enough time and financial resources to build a fullfledged drug development chain transfer some or all phases of development and ...
Sergey U. Chernikov, Alexander M. Zobov, Ekaterina A. Degtereva   +2 more
doaj   +1 more source

The Workforce Needs of New Jersey's Pharmaceutical and Medical Technology Industry [PDF]

, 2007
This report is based on an online survey conducted in spring 2006 of pharmaceutical and medical technology companies in New Jersey. It identifies the current and future workforce needs of the pharmaceutical and medical technology industry in New ...

core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Graph-theoretical optimization of the aspirin synthesis pathway: Enhancing green chemistry in pharmaceutical manufacturing

Computational and Mathematical Biophysics
Aspirin, one of the most widely produced and consumed pharmaceuticals globally, presents an ideal case for exploring sustainable synthesis methods in pharmaceutical manufacturing.
Rooban Sanjai Shanmugavel Kannan, Nagarathinam Rangarajan   +1 more
doaj   +1 more source

Regional technology gap and innovation efficiency trap in Chinese pharmaceutical manufacturing industry

PLoS ONE, 2020
Objective There is a huge technology gap between regions in Chinese pharmaceutical manufacturing industry, which is the reality that must be faced. However, most of the available researches on innovation efficiency are based on the logic of a given ...
Hongbo Lai, Hao Shi, Yang Zhou
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Design Space Identification and Visualization for Continuous Pharmaceutical Manufacturing

Pharmaceutics, 2020
Progress in continuous flow chemistry over the past two decades has facilitated significant developments in the flow synthesis of a wide variety of Active Pharmaceutical Ingredients (APIs), the foundation of Continuous Pharmaceutical Manufacturing (CPM),
Samir Diab, Dimitrios I. Gerogiorgis
semanticscholar   +1 more source