Results 111 to 120 of about 212,580 (355)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Glycyrrhizic acid and its carrier-free micellar formulation: Unraveling the potential for enhanced oral prevention of hearing loss

International Journal of Pharmaceutics: X
Hearing loss, a global health concern, significantly impacts patients with delayed language development, impaired neurocognitive function, and severe social problems.
Huaan Li, Bohan Lin, Shuangwu Wang, Ying Zhang, Zeming Zhou, Dingsheng Wen, Zhifeng Zhang, Xiaohua Feng, Lu Wen, Jun He, Gang Chen   +10 more
doaj   +1 more source

Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations. [PDF]

Pharmaceutics, 2023
Ramos P, Raczak BK, Silvestri D, Wacławek S.   +3 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

MicroRNA-19a-3p inhibits endothelial dysfunction in atherosclerosis by targeting JCAD

BMC Cardiovascular Disorders
Objective To examine the influences and mechanisms of MicroRNA-19a-3p (miR-19a-3p) on endothelial dysfunction in atherosclerosis. Methods An analysis of miR-19a expression was carried out using the Gene Expression Omnibus (GEO) database.
Jinque Luo, Ling Wang, Chaoyue Cui, Hongyu Chen, Wanli Zeng, Xin Li   +5 more
doaj   +1 more source

The influence of washed microbiota transplantation on menstruation in female patients of childbearing age

Frontiers in Endocrinology
Background and aimsMenstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, and menstrual ...
Qingting Wu, Qingting Wu, Mingzhu Wang, Mingzhu Wang, Juan Yang, Juan Yang, Jiangyan Wang, Jiangyan Wang, Shuo Feng, Shuo Feng, Shenghua Lu, Shenghua Lu, Zhichu Qin, Zhichu Qin, Xingxiang He, Xingxiang He, Lei Wu, Lei Wu   +17 more
doaj   +1 more source

TLC-Densitometry for Determination of Omeprazole in Simple and Combined Pharmaceutical Preparations. [PDF]

Pharmaceuticals (Basel), 2022
Parys W, Pyka-Pająk A.
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

All-in-one peptide with sequential pH gradient sensing capabilities for the targeted delivery and deep penetration of nanomicelles against breast cancer

Asian Journal of Pharmaceutical Sciences
Antitumor nanomedicines are usually decorated with ligands to achieve multiple functions, such as targeting delivery, tissue penetration and enhanced cellular uptake.
Qinying Chen, Xinao Liu, Zijin Tan, Zhihao Liu, Zijie Qiu, Yerong Xiong, Jiasheng Tu, Yanping Wu, Chunmeng Sun   +8 more
doaj   +1 more source

Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomized controlled trials

Journal of Rehabilitation Medicine, 2019
Objective: To investigate the efficacy and safety of drug interventions to promote motor recovery post-stroke. Data sources: CENTRAL, CINAHL, Embase, MEDLINE, SCOPUS and Web of Science.
Nerida Firth, Ruth N. Barker, Kathryn S. Hayward, Julie Bernhardt, Michelle Bellingan, Ronny Gunnarsson   +5 more
doaj   +1 more source