Results 91 to 100 of about 99,369 (311)

Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke   +5 more
wiley   +1 more source

Glycyrrhizic acid and its carrier-free micellar formulation: Unraveling the potential for enhanced oral prevention of hearing loss

open access: yesInternational Journal of Pharmaceutics: X
Hearing loss, a global health concern, significantly impacts patients with delayed language development, impaired neurocognitive function, and severe social problems.
Huaan Li   +10 more
doaj   +1 more source

Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomized controlled trials

open access: yesJournal of Rehabilitation Medicine, 2019
Objective: To investigate the efficacy and safety of drug interventions to promote motor recovery post-stroke. Data sources: CENTRAL, CINAHL, Embase, MEDLINE, SCOPUS and Web of Science.
Nerida Firth   +5 more
doaj   +1 more source

Characterization of functionalized calcium carbonate as a new pharmaceutical excipient [PDF]

open access: yes, 2014
Excipients are indispensable functional components, which are used to develop innovative, robust, and reproducible formulations with good patient compliance due to optimized plasma concentrations and less side effects.
Stirnimann, Tanja
core   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub   +24 more
wiley   +1 more source

MicroRNA-19a-3p inhibits endothelial dysfunction in atherosclerosis by targeting JCAD

open access: yesBMC Cardiovascular Disorders
Objective To examine the influences and mechanisms of MicroRNA-19a-3p (miR-19a-3p) on endothelial dysfunction in atherosclerosis. Methods An analysis of miR-19a expression was carried out using the Gene Expression Omnibus (GEO) database.
Jinque Luo   +5 more
doaj   +1 more source

All-in-one peptide with sequential pH gradient sensing capabilities for the targeted delivery and deep penetration of nanomicelles against breast cancer

open access: yesAsian Journal of Pharmaceutical Sciences
Antitumor nanomedicines are usually decorated with ligands to achieve multiple functions, such as targeting delivery, tissue penetration and enhanced cellular uptake.
Qinying Chen   +8 more
doaj   +1 more source

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