Results 41 to 50 of about 99,751 (312)

Comité de Expertos de la OMS en Especificaciones para las Preparaciones Farmacéuticas [se reunió en Ginebra del 3 al 9 de noviembre de 1964] : 21o informe [PDF]

, 1965
35 ...
World Health Organization, WHO Expert Committee on Specifications for Pharmaceutical Preparations. Meeting   +1 more
core   +1 more source

Pedalitin could regulate lipid metabolism and attenuate inflammatory factors in a non-alcoholic fatty liver disease cell model

Journal of Holistic Integrative Pharmacy
Nonalcoholic fatty liver disease (NAFLD) is an escalating global health issue, leading to liver fat accumulation, inflammation, fibrosis, and potential liver failure.
Wanying He, Yaying Yu, Hui He, Qian Huang, Zhiting Liu, Fan Yang, Lin Zhou   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Washed microbiota transplantation improves clinical symptoms, gut microbiota, and metabolic profiles in autism spectrum disorder in a twin cohort

Frontiers in Microbiology
ObjectiveAutism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by impaired social communication, repetitive behaviors, and restricted interests.
Shuo Feng, Shuo Feng, Xinyu Si, Xinyu Si, Caimei Lu, Caimei Lu, Zheng Gao, Zheng Gao, Jiangyan Wang, Jiangyan Wang, Qingqing Yang, Qingqing Yang, Shenghua Lu, Shenghua Lu, Ting Su, Ting Su, Juan Yang, Juan Yang, Xingxiang He, Xingxiang He, Lei Wu, Lei Wu   +21 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations [PDF]

, 2018
A pharmaceutical suspension is a semi-liquid dosage form suitable for patients being unable to swallow solid medicines such as tablets and capsules. A vehicle used for the preparation of pharmaceutical oral suspensions preferably shows pseudo-plastic ...
Hinrichs, Wouter L J, Ten Seldam, Inge E J, Woerdenbag, Herman J, Woerdenbag, Herman J; id_orcid, van der Linden, Isabella J, Hinrichs, Wouter L J; id_orcid, Dijkers, Eli C F, Visser, J Carolina, Veenendaal, Reinier F H   +8 more
core  

ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway

Molecular Medicine
Osteoporosis (OP) is a common systemic metabolic bone disease characterized by the decrease in bone mass and hyperactivity of osteoclasts. ACT001 is approved as an orphan drug by FDA and has shown multiple protective effects against tissue injury ...
Yuan Li, Jin-Yu Yang, Ma-Li Lin, Tian-Zhu Liu, Wen-Na Lu, Ying Yang, Zhong-Cheng Liu, Jian-Heng Li, Guo-Qiang Zhang, Jian-Shuang Guo   +9 more
doaj   +1 more source

(Benzo[h]quinoline-κ²C,N)-[2,2′-bis(diphenylphosphino)-1,1′-binaphthalene-κ²P,P′]-platinum(II) Hexafluorophosphate

Molbank
A cyclometalated platinum(II) complex [Pt(bzq)(BINAP)]PF6 bearing a 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene (BINAP) auxiliary ligand and a cyclometalated benzo[h]quinoline (bzq) ligand have been prepared.
Haoni Wang, Meiting Zhang, Jianwei Wu, Junqi Zhang, Xianglong Meng, Yuliang Yang   +5 more
doaj   +1 more source

The crystal structure of aqua-bis(6-chloropicolinato-κ2N,O)copper(II), C12H8Cl2N2O5Cu

Zeitschrift für Kristallographie - New Crystal Structures, 2021
C12H8Cl2N2O5Cu, triclinic, P1‾$P‾{1}$ (no. 2), a = 6.800(2) Å, b = 9.086(3) Å, c = 11.363(4) Å, α = 86.701(6)°, β = 84.830(5)°, γ = 77.353(5)°, V = 681.7(4) Å3, Z = 2, Rgt(F) = 0.0250, wRref(F2) = 0.0655, T = 296(2) K.
Zhang Zhongyu, Tong Mingqiong, Liu Yanling   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source