Results 51 to 60 of about 821,942 (298)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Washed microbiota transplantation improves clinical symptoms, gut microbiota, and metabolic profiles in autism spectrum disorder in a twin cohort

Frontiers in Microbiology
ObjectiveAutism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by impaired social communication, repetitive behaviors, and restricted interests.
Shuo Feng, Shuo Feng, Xinyu Si, Xinyu Si, Caimei Lu, Caimei Lu, Zheng Gao, Zheng Gao, Jiangyan Wang, Jiangyan Wang, Qingqing Yang, Qingqing Yang, Shenghua Lu, Shenghua Lu, Ting Su, Ting Su, Juan Yang, Juan Yang, Xingxiang He, Xingxiang He, Lei Wu, Lei Wu   +21 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Pharmaceutical preparations, except biologicals : 2004 [PDF]

, 2005
Current industrial report.

core  

ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway

Molecular Medicine
Osteoporosis (OP) is a common systemic metabolic bone disease characterized by the decrease in bone mass and hyperactivity of osteoclasts. ACT001 is approved as an orphan drug by FDA and has shown multiple protective effects against tissue injury ...
Yuan Li, Jin-Yu Yang, Ma-Li Lin, Tian-Zhu Liu, Wen-Na Lu, Ying Yang, Zhong-Cheng Liu, Jian-Heng Li, Guo-Qiang Zhang, Jian-Shuang Guo   +9 more
doaj   +1 more source

(Benzo[h]quinoline-κ²C,N)-[2,2′-bis(diphenylphosphino)-1,1′-binaphthalene-κ²P,P′]-platinum(II) Hexafluorophosphate

Molbank
A cyclometalated platinum(II) complex [Pt(bzq)(BINAP)]PF6 bearing a 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene (BINAP) auxiliary ligand and a cyclometalated benzo[h]quinoline (bzq) ligand have been prepared.
Haoni Wang, Meiting Zhang, Jianwei Wu, Junqi Zhang, Xianglong Meng, Yuliang Yang   +5 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Quality evaluation of a traditional Chinese medicine compound preparation containing Rhodiola rosea, Astragalus membranaceus, and Carthamus tinctorius

Frontiers in Analytical Science
ObjectiveWe aim to improve the quality control of Rhodiola rosea, Astragalus membranaceus, and Carthamus tinctorius capsules (RAC capsule) from the aspects of thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC), respectively,
Zhisen Wang, Zhisen Wang, Sisi Guo, Sisi Guo, Jun Chen, Jun Chen, Lu Wang, Lu Wang, Huicong Zhang, Huicong Zhang, Xiaocan Cui, Xiaocan Cui, Bingling Zhao, Bingling Zhao, Shihui Ge, Shihui Ge, Sai Li, Sai Li, Mengliang Zhu, Mengliang Zhu, Peipei Xing   +20 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Pharmaceutical preparations, except biologicals : 2006 [PDF]

, 2007
Current industrial report.

core