Results 61 to 70 of about 821,942 (298)

The crystal structure of aqua-bis(6-chloropicolinato-κ2N,O)copper(II), C12H8Cl2N2O5Cu

open access: yesZeitschrift für Kristallographie - New Crystal Structures, 2021
C12H8Cl2N2O5Cu, triclinic, P1‾$P‾{1}$ (no. 2), a = 6.800(2) Å, b = 9.086(3) Å, c = 11.363(4) Å, α = 86.701(6)°, β = 84.830(5)°, γ = 77.353(5)°, V = 681.7(4) Å3, Z = 2, Rgt(F) = 0.0250, wRref(F2) = 0.0655, T = 296(2) K.
Zhang Zhongyu   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Sulfafurazole dimers potentiate chemo-immunotherapy of low immunogenic breast cancer by preventing the PD-L1 exosomes secretion

open access: yesActa Pharmaceutica Sinica B
The αPD-L1 antibody-based immune checkpoint blockade therapy is still limited by the poor clinical response rate as it is mainly utilized to block surface PD-L1 on tumor cells while ignoring abundant PD-L1 exosomes secreted in the environment, causing ...
Zheng Wang   +5 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

Nineteenth report / Expert Committee on Specifications for Pharmaceutical Preparations

open access: yes, 1962
"The Expert Committee on Specifications for Pharmaceutical Preparations met in Geneva from 27 November-1 December 1961"27 ...
World Health Organization   +1 more
core  

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

Seventeenth report / Expert Committee on Specifications for Pharmaceutical Preparations

open access: yes, 1960
"The Expert Committee on Specifications for Pharmaceutical Preparations met in Geneva from 9-14 November 1959"WHO/Pharm/37733 ...
World Health Organization   +1 more
core  

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