Results 41 to 50 of about 1,067,890 (357)

Avenanthramides as lipoxygenase inhibitors

Heliyon, 2020
Avenanthramides (AVAs) present in oats are amides of anthranilic and cinnamic acids. AVAs are potent antioxidants and have anti-inflammatory properties.
Rikard Landberg, Kerstin Sunnerheim, Lena H. Dimberg   +2 more
doaj   +1 more source

Pharmacy Curriculum Outcomes Assessment (PCOA) as Predictor of Performance on NAPLEX [PDF]

, 2015
Objectives: The purpose of the study was to respond to students’ inquiry regarding the relationship between student performance on the PCOA administered in early spring of the P3 year and performance on the NAPLEX administered post-graduation.
Hutchinson, David, Lenhard, Lalani, Souza, Jane M.   +2 more
core  

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Dinutuximab beta effectively treats Ewing sarcoma when combined with chemotherapy

iScience
Summary: Ewing sarcoma is a rare and aggressive cancer of the bone and soft tissues primarily affecting children and young adults. Prognosis for patients with metastatic or recurrent disease remains poor despite intensive multimodal therapy, highlighting
Roberta Frapolli, Marina Meroni, Ezia Bello, Lorenza Pirona, Elisa Callegari, Valentina Kebede, Isabella Pellerani, Simone Canesi, Eugenio Scanziani, Uta Dirksen, Patrizia Angelico, Stefano Biondi, Matteo Malinverno   +12 more
doaj   +1 more source

Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects

Heliyon, 2019
Anxiety disorders, depression and pain are highly prevalent pathologies. Their pharmacotherapy is associated with unwanted side effects; hence there is a clinical need to develop more effective drugs with fewer adverse reactions.Chalcones are one of the ...
Josefina Higgs, Cristina Wasowski, Alejandra Marcos, Marko Jukič, Carlos Humberto Paván, Stanislav Gobec, Felicitas de Tezanos Pinto, Natalia Colettis, Mariel Marder   +8 more
doaj   +1 more source

Geographic proximity and firm-university innovation linkages: evidence from Great Britain [PDF]

, 2008
We investigate evidence for spatially mediated knowledge transfer from university research. We examine whether firms locate their R&D labs near universities, and whether those that do are more likely to co-operate with, or source knowledge from ...
Abramovsky, L., Simpson, H.
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Microscale pressure measurements and optical coherence tomography reveal time-dependent biomechanical stages of ovulation in mice

iScience
Summary: During ovulation, antral follicles undergo coordinated remodeling that results in egg release and corpora lutea formation, which are key processes for fertility and endocrine function. Using an ex vivo murine ovulation model integrated with time-
Emily J. Zaniker-Gomez, Zihang Yan, Jing Yang, Darryl L. Russell, Hao Zhang, Sean X. Sun, Francesca E. Duncan   +6 more
doaj   +1 more source

Recent advances in pharmaceutical sciences VII [PDF]

, 2017
The E-book series Recent Advances in Pharmaceutical Sciences reports research contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences.
Feliu José, Carlos, Muñoz-Torrero López-Ibarra, Diego, Riu Aumatell, Montserrat   +2 more
core  

The parallel lives of polysaccharides in food and pharmaceutical formulations [PDF]

, 2015
The present opinion article discusses how polysaccharide structures can be used in both food and pharmaceutical formulations. We distinguish two regions depending on moisture content where polysaccharides form structures with distinct functional ...
Kontogiorgos, Vassilis, Morris, G.A., Smith, Alan M.   +2 more
core   +1 more source