Results 41 to 50 of about 461,561 (166)

Design and optimization of resveratrol-loaded porous calcium silicate powders for dissolution and photostability enhancement

Heliyon, 2019
In this study, resveratrol (RVT) was loaded onto porous calcium silicate (PCS) powders to improve its dissolution and photostability properties. The effects of RVT/PCS powders that included varying amounts of low-methoxyl pectin (LMP), ethyl acetate (EA)
Pontip Benjasirimongkol, Suchada Piriyaprasarth, Pornsak Sriamornsak   +2 more
doaj   +1 more source

In vitro antileishmanial activity of Mexican medicinal plants

Heliyon, 2017
Aim of the study: To evaluate the anti-leishmanial activity and cytotoxicity of aqueous and organic extracts of ten plants used in Mexican traditional medicine as anti-parasitics.
Ronna Delgado-Altamirano, Lianet Monzote, Abel Piñón-Tápanes, Heike Vibrans, J. Fausto Rivero-Cruz, César Ibarra-Alvarado, Alejandra Rojas-Molina   +6 more
doaj   +1 more source

Development of a hybrid CFD-PBPK model to predict the transport of xenon gas around a human respiratory system to systemic regions

Heliyon, 2019
Administering incorrect doses of conventional anesthetic agents through the pulmonary route can cause potential health risks such as blood coagulation, platelet dysfunction, and deteriorating organ function.
Ahmadreza Haghnegahdar, Jianan Zhao, Max Kozak, Patrick Williamson, Yu Feng   +4 more
doaj   +1 more source

An NLP-based technique to extract meaningful features from drug SMILES

iScience
Summary: NLP is a well-established field in ML for developing language models that capture the sequence of words in a sentence. Similarly, drug molecule structures can also be represented as sequences using the SMILES notation.
Rahul Sharma, Ehsan Saghapour, Jake Y. Chen   +2 more
doaj   +1 more source

Data Science in Pharmaceutical Industry

, 2020
Data Science demand from Medical Affairs (MA) functions in the pharmaceutical industry are exponentially increasing, where business cases around more modern execution of activities and strategic planning are becoming a reality. MA is still lagging in terms of implementing data science and big data technology in the current times, which means a ...
Pesqueira, A., Sousa, M. J., Rocha, Á., Sousa, M.   +3 more
openaire   +2 more sources

Application of hydrophilic interaction liquid chromatography for the quantification of succinylcholine in Active Pharmaceutical Ingredient and medicinal product. Identification of new impurities of succinylcholine chloride

Heliyon, 2018
A new method, using hydrophilic interaction chromatography (HILIC), for quantification of succinylcholine and impurities in Active Pharmaceutical Ingredient (API), as well as in the medicinal product, was developed.
Arkadiusz Szterk, Adam Zmysłowski, Shela Gorinstein   +2 more
doaj   +1 more source

Proportionality between powder cohesion and unconfined yield strength from shear cell testing

Heliyon, 2019
From an analysis of the geometry of the yield locus and the Mohr's circle for determining unconfined yield strength (fc) in shear cell testing, it has been shown that powder cohesion is proportional to fc, where the proportionality constant is a function
David J. Sun, Changquan Calvin Sun
doaj   +1 more source

Scientific basis of the development and standardization of herbal medicines

Регуляторные исследования и экспертиза лекарственных средств, 2018
The present paper conceptually considers scientific approaches to standardization of starting materials of herbal origin and herbal medicinal products.
I. A. Samylina, V. A. Kurkin, G. P. Yakovlev   +2 more
doaj  

Permeability of frog skin to chemicals: effect of penetration enhancers

Heliyon, 2019
Rarely do commercial chemical products contain solely the active chemical/ingredient. It is therefore important to consider whether ingredients other than the active may: 1) alter absorption of the active chemical, or 2) be absorbed themselves, resulting
Victoria K. Llewelyn, Lee Berger, Beverley D. Glass   +2 more
doaj   +1 more source

The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds

Heliyon, 2018
An mRNA gene therapy represents a potentially promising therapeutic for curing inflammatory diseases. The transient nature of the gene expression of mRNA would be expected to be beneficial for avoiding undesired side effects.
Hiroki Tanaka, Ayaka Watanabe, Manami Konishi, Yuta Nakai, Hiroki Yoshioka, Tatsuya Ohkawara, Hiroshi Takeda, Hideyoshi Harashima, Hidetaka Akita   +8 more
doaj   +1 more source