Results 81 to 90 of about 5,230,993 (373)
Heliyon, 2019 Superficial fungal infection in immunocompromised patients can lead to many disorders and complications. Currently, new topical treatment options are critically needed to treat these fungal infections.
Manish Kumar +4 more
doaj
Mono- and combinational drug therapies for global viral pandemic preparedness
iScience, 2022 Summary: Broadly effective antiviral therapies must be developed to be ready for clinical trials, which should begin soon after the emergence of new life-threatening viruses.
Aleksandr Ianevski +17 more
doaj
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
In vitro antileishmanial activity of Mexican medicinal plants
Heliyon, 2017 Aim of the study: To evaluate the anti-leishmanial activity and cytotoxicity of aqueous and organic extracts of ten plants used in Mexican traditional medicine as anti-parasitics.
Ronna Delgado-Altamirano +6 more
doaj +1 more source
Electron diffraction determines molecular absolute configuration in a pharmaceutical nanocrystal
Science, 2019 Dynamical refinement spots a difference For chiral molecules used in drugs, one isomer can have beneficial bioactivity, whereas the others are useless or even harmful.
P. Brázda, L. Palatinus, M. Babor
semanticscholar +1 more source
Crystallization for Pharmaceutical and Food Science
Current Pharmaceutical Design, 2018 Xichang Wang +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley +1 more source
The impact of public basic research on industrial innovation: Evidence from the pharmaceutical industry [PDF]
While most economists believe that public scientific research fuels industry innovation and economic growth, systematic evidence supporting this relationship is surprisingly limited. In a recent study, Acemoglu and Linn (2004) identified market size as a
Toole, Andrew A.
core
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Problem of working out the objective and subjective fundamentals of pharmacy [PDF]
, 2015 We have shown the necessity of substantiation of the status of pharmacy as an independent science and theoretical comprehension of pharmacy as a system of scientific knowledge.
Razdorskaya, I. M., Spichak, I. V.
core