Results 101 to 110 of about 1,046,192 (353)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Market Structure and Drug Innovation [PDF]

An explosion of knowledge and a growing array of tools and technologies have transformed modern drug R&D, while its cost has risen by a sizable amount.
Pammolli, Fabio, Riccaboni, Massimo
core   +1 more source

World Journal of Pharmaceutical Sciences

, 2021

openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Pharmaceutical Regulatory Science

International Journal of Pharmaceutical Research and Applications
TitlePharmaceutical Regulatory Science Authors / Editors Editor: Dr. Ravi Shankar Tripathi Co-Editor: Dr. Pravin Badhe Contributing Authors: Sushmita Hiremath; Nikhil Gawas; Bono Naga Sudha; Thokala Ujwala Reddy; Kanchanam AshaDeepthi; Shaik Shabana; Dr. Vivek R. Mallurwar; Reema Sanghvi; Dr.
Dr. Ravi Shankar Tripathi, Sushmita Hiremath, Nikhil Gawas, Bono Naga Sudha, Thokala Ujwala Reddy, Kanchanam AshaDeepthi, Shaik Shabana, Dr. Vivek R. Mallurwar, Reema Sanghvi, Dr. Sivakumar Kullampalayam Krishnasamy., Dr. Abinaya Mouralidasse, Yarra Sai Phanindra, Mrs. Kandregula Kesava Uma Maheswari   +1 more
openaire   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Policy Analysis Of Iranian Pharmaceutical Sector; A Qualitative Study

Risk Management and Healthcare Policy, 2019
Farbod Ebadi Fardazar,1 Ali Sarabi Asiabar,2 Hossein Safari,1 Mojgan Asgari,3 Ali Saber,4 Amir Ali Ebadi Fard Azar5 1School of Public Health, Health Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran; 2School of Health ...
Ebadi Fardazar F, Sarabi Asiabar A, Safari H, Asgari M, Saber A, Ebadi Fard Azar AA   +5 more
doaj  

Enhanced Accumulation of Cisplatin in Ovarian Cancer Cells from Combination with Wedelolactone and Resulting Inhibition of Multiple Epigenetic Drivers

Drug Design, Development and Therapy, 2021
Sadia Sarwar,1,2 Abir A Alamro,3 Amani A Alghamdi,3 Komal Naeem,4 Salamat Ullah,5 Muazzam Arif,6 Jun Qing Yu,1 Fazlul Huq7 1Discipline of Biomedical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus, Sydney, NSW, Australia ...
Sarwar S, Alamro AA, Alghamdi AA, Naeem K, Ullah S, Arif M, Yu JQ, Huq F   +7 more
doaj  

The opioid receptor: emergence through millennia of pharmaceutical sciences. [PDF]

Front Pain Res (Lausanne), 2023
Fairbanks CA, Peterson CD.
europepmc   +1 more source

Equitable Impacts of Coaching Reports on Pre-PharmD Students Self-Directed Learning and Pharmaceutical Science Exam Performance

, 2023
Hannah Hoffmann, Nicholas Denton
openalex   +1 more source