Results 81 to 90 of about 5,300,619 (282)

Risk Factors Which Effect the Maturity of Placenta

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Back ground Proper placental development is essential for a successful pregnancy. An important organ, the placenta carries out several physiological, immunological, and endocrine functions. It also performs vital roles in mediating the exchange of gasses,
Eftkar Hamza Skair, Saadya Hadi Humade, Rania Abd Elmohsen Abo El nour, Maryam Amer Ajam   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Preparation and Characterization Using a New Schiff Base Ligand Derived from Benzoyl Isothiocyanate with Their Complexes and Study of Their Biological Activity

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Complexes containing Nickel, Copper, and Zinc salts were prepared and studied in this study. Additionally, novel Schiff Base ligands were synthesized by reacting 6-aminopenicillinic acid with benzoyl isothiocyanate to produce L.
Zaynab Faleh AI-Janahi, Mohammed Hamid Said   +1 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

DICLOFENAC: A Review on Its Synthesis, Mechanism of Action, Pharmacokinetics, Prospect and Environmental Impact

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Diclofenac, potent a nonsteroidal anti-inflammatory drug, used in the treatment of inflammation, pain and fever associated with a wide range of disease condition.
Hind A. Satar, Emad Yousif, Ahmed Ahmed   +2 more
doaj   +1 more source

Recent Advances in Liquid Chromatography–Mass Spectrometry (LC–MS) Applications in Biological and Applied Sciences

Analytical Science Advances
Liquid chromatography–mass spectrometry (LC–MS) is a highly sophisticated analytical technique that has become indispensable for sample analysis across various scientific domains.
Samyah Alanazi
semanticscholar   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A Meta-Analysis Comparing Surgical Site Wound Infection following Single-Incision versus Multiple-Incision Video-Assisted Thoracoscopic Surgery Lobectomy for Patients with Lung Cancer

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background A meta-analysis was conducted to evaluate the impact of single-incision (SI) versus multiple-incision (MI) video-assisted thoracoscopic surgery (VATS) lobectomy on surgical site wound length (SSWL) and surgical site wound infection (SSWI) in ...
Zainab Ayad
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Occurrence and Diversity of Staphylococcus from Women with Breast Abscess and Mastitis

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Mastitis is inflammatory that can effect women at every time , it is predominant occur in women during breastfeeding. Staphylococcus are the most common pathogens causative agents of mastitis.The clincal samples were collection from women with different ...
Rana Adnan M. Al-Wataify, Maysaa S.M. Al-Shukri, Mohend A.N Al-Shalah   +2 more
doaj   +1 more source