Results 71 to 80 of about 603,038 (294)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Dinutuximab beta effectively treats Ewing sarcoma when combined with chemotherapy
iScienceSummary: Ewing sarcoma is a rare and aggressive cancer of the bone and soft tissues primarily affecting children and young adults. Prognosis for patients with metastatic or recurrent disease remains poor despite intensive multimodal therapy, highlighting
Roberta Frapolli +12 more
doaj +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Çözünürlüğü Düşük Olan Etken Maddeler İçin Farmasötik Yaklaşımlar ve Aprepitantın Çözünürlüğü
, 2021 Advances in technology have broken new ground in the area of new active pharmaceutical ingredients discovery. Although the number of newly discovered active ingredients increases, only a few of them manage to survive for further development. even if some
Mesut B., Özsoy Y., Nazli H.
core
Future Journal of Pharmaceutical Sciences
, 2015 Future Journal of Pharmaceutical Sciences issued under the auspicious of Future University in Egypt. The Journal publishes communications, original research articles, review articles and case studies on all aspects of the pharmaceutical ...
core +1 more source
Computational pharmaceutical materials science [PDF]
Journal of Cheminformatics, 2014 Pharmaceutical materials science addresses the physical solid-state properties of pharmaceutical products, such as solubility and stability of crystal structures. Especially the different properties of different polymorphs, salts and hydrates of an Active Pharmaceutical Ingredient (API) are of interest, although more recently the amorphous state has ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
กลยุทธการเพิ่มการสร้างสาร naphthoquinone ในรากเพาะเลี้ยงของเทียนบ้าน [PDF]
, 2010 Thesis (Ph.D., Pharmaceutical Sciences)--Prince of Songkla University ...
Athip Sakunphueak
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From Pharmacy to Pharmaceutical Sciences – The New Curriculum
CHIMIA, 2004 Looking at the statistics of Pharmacy graduates, the picture has changed considerably over the last 25 years. In the 1980s at least 80% of the diploma students chose an occupation in a community pharmacy.
Heidi Wunderli-Allenspach
doaj +1 more source