Results 51 to 60 of about 1,056,595 (308)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Experience of and Attitudes toward Research among Pharmaceutical Sciences and PharmD Students in Saudi Arabia

open access: yesHealth Professions Education, 2019
Purpose: The aim of this study was to investigate attitudes toward, experience of, and perceived barriers to conducting research among Pharmaceutical Sciences and Doctor of Pharmacy (PharmD) students in pharmacy colleges in Saudi Arabia.
Rahaf Ali Alqahtani   +5 more
doaj   +1 more source

Quality of Herbal Medicines: New Aspects and Solutions

open access: yesРегуляторные исследования и экспертиза лекарственных средств, 2023
Herbal drugs and herbal medicinal products remain of interest to Russian researchers both in terms of the development, efficacy, and safety of medicines, and in terms of the research methodology applicable to these medicine, as well as the use of new ...
V. G. Luzhanin   +2 more
doaj   +1 more source

Analysis of Compounded Pharmaceutical Products to Teach the Importance of Quality in an Applied Pharmaceutics Laboratory Course [PDF]

open access: yes, 2014
Objective. To assess the effectiveness of a product-analysis laboratory exercise in teaching students the importance of quality in pharmaceutical compounding. Design.
Almoazen   +9 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Special issue: Pharmaceutical innovation

open access: yesAsian Journal of Pharmaceutical Sciences, 2018
“Pharmaceutical innovation” is an interdisciplinary area of the pharmaceutical sciences including drug development with a focus on manufacturing, process control, and technology, among many other subfields of research.
Pornsak Sriamornsak   +1 more
doaj   +1 more source

Quality Assurance of Medicines: Main Scientific Approaches and Control Methods

open access: yesРегуляторные исследования и экспертиза лекарственных средств, 2023
The most important component of national health policy is the assurance of quality, efficacy, and safety of medicines entering the pharmaceutical market in the Russian Federation. In this interview, we have discussed the quality control of medicines; its
E. L. Kovaleva   +2 more
doaj   +1 more source

The Method of Forecasting of the Indicators for Drug Reimbursement to Patients with Cardiovascular Diseases in Ukraine [PDF]

open access: yes, 2019
The aim of the study is to develop a method for forecasting the indicators for drug reimbursement to patients with cardiovascular diseases (CVD) in Ukraine within the framework of the government program “Available medicines”.Materials and methods ...
Kurylenko, Y. (Yuliia)   +2 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hydrophilic Matrices for Oral Control Drug Delivery [PDF]

open access: yes, 2015
Oral controlled drug delivery has gathered tremendous attention over the years due to its many advantages over conventional dosage forms. Polymer-based matrices have become an integral part of the pharmaceutical industry. Hydrophilic matrices are capable
Conway, Barbara R, Ghori, Muhammad U.
core   +1 more source

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