Results 91 to 100 of about 5,300,619 (282)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A Study of Serum Levels of Ferritin, Hepatic and Renal functions in Beta-Thalassemia Major (BTM) Patients Treated With Deferasirox (DFX) Tablets, Desferioxamine (DFO) Vial, or Combination of Both (DFX + DFO) in Thalassemia Center/Karbala

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
A category of inherited blood illnesses known as beta-thalassemias are defined by abnormalities in the synthesis of hemoglobin beta chains, which can result in a wide range of phenotypes, from severe anemia to people who show no symptoms at all.
Shereen M. Mekkey, Maysam Ali Ameen, Najwa Kahtan Hadi   +2 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Crafting Lornoxicam-infused Microsponges for Elevated Efficacy in Inflammatory Disorders

Bulletin of Faculty of Pharmacy Cairo University
Introduction: Lornoxicam (LRX), a member of the Oxicam class of non-steroidal anti-inflammatory drugs (NSAIDs), exhibits potent analgesic, anti-inflammatory, and antipyretic properties.
Vishal Yadav, Pooja Kachare
doaj   +1 more source

Advances in polysaccharide‐based materials for biomedical and pharmaceutical applications: A comprehensive review

Archiv der Pharmazie
Polysaccharides, the most abundant biopolymers in nature, have attracted the attention of researchers and clinicians due to its practicality in biomedical and pharmaceutical sciences.
Jiahao Li, H. Ahmed, Ali M Hussein, Mandeep Kaur, Mohammed Khaleel Jameel, Harpreet Kaur, Umida Tillaeva, A. F. Al-Hussainy, Hayder Naji Sameer, Huda Ghassan Hameed, A. H. Idan, Fahad Alsaikhan, Asghar Narmani, Bagher Farhood   +13 more
semanticscholar   +1 more source

Applications of AFM in Pharmaceutical Sciences

, 2016
Atomic force microscopy (AFM) is a high-resolution imaging technique that uses a small probe (tip and cantilever) to provide topographical information on surfaces in air or in liquid media. By pushing the tip into the surface or by pulling it away, nanomechanical data such as compliance (stiffness, Young’s Modulus) or adhesion, respectively, may be ...
Lamprou, Dimitrios, Smith, James R.
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Effect of Rehabilitation Exercises and Antioxidants on Patients with Stable Heart Failure

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
The research aims to find out the effect of rehabilitation exercises and antioxidants in some physical and physiological abilities, free radicals and the degree of pain for patients with stable heart failure, and the research sample was selected randomly
Shimaa Mohamed Abu Zeid, Walid A. Ali
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source