Results 101 to 110 of about 263,791 (359)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Integrated electronic prescribing and robotic dispensing: a case study [PDF]

, 2013
INTRODUCTION: To quantify the benefits of electronic prescribing directly linked to a robotic dispensing machine. CASE DESCRIPTION: Quantitative case study analysis is used on a single case.
C Whittlesea, DL Kelley, J Beard, JM Smith, L Donaldson, R Beard, R Beard, RK Yin   +7 more
core   +1 more source

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

The potential influence of estrogen-containing oral contraception on clozapine metabolism in a patient with known pharmacogenomic status [PDF]

Mental Health Clinician
Clozapine is primarily metabolized via cytochrome P450(CYP)1A2 and to a lesser extent CYP3A4, CYP2C19, and CYP2D6. Metabolic inhibitors of clozapine, such as fluvoxamine and ciprofloxacin, are important to recognize to avoid adverse drug events. Estrogen-
Alyssa K. Kuhn, Meina L. Determan, Jessica A. Wright, PharmD, Eric Matey, Jonathan G. Leung   +4 more
doaj   +1 more source

Medical Marijuana and Pharmacy Practice [PDF]

, 2015
By way of the Compassionate Care Act of 2014, New York has become the 23rd state to create a process that will permit patients suffering from a “serious condition” to receive medical marijuana (or “cannabis”).
Williams, Karl G
core   +1 more source

Desarrollo de una taxonomía de las intervenciones farmacéuticas en pacientes VIH+ basados en el modelo CMO [PDF]

, 2016
Objective: To agree on a proposal for pharmaceutical interventions and establish their classification taxonomy according to the CMO-Pharmaceutical Care Model (Capacity-Motivation- Opportunity). Method: A study conducted between March and May, 2016.
Aguas Robustillo-Cortés, María de las, Morillo Verdugo, Ramón Alejandro, Villarreal Arévalo, Andrea Lisbeth, Álvarez de Sotomayor Paz, María   +3 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

BREAST CANCER ASSISTANCE JOURNEY FROM THE PERSPECTIVE OF THE PUBLIC HEALTHCARE SERVICE OF RIO GRANDE DO SUL

Jornal de Assistência Farmacêutica e Farmacoeconomia
Objective: This study aims to characterize the breast cancer (BC) patient journey in Rio Grande do Sul (RS), Brazil, through the perspectives of the High Complexity Oncology Assistance Centers (CACONs) and High Complexity Oncology Assistance Units ...
Fernando Anschau, Sabrina Bedin, Luciane Kopittke, Tamie de Camargo Martins, Ruth Grigolon, Isabel Monteiro, Giovanna da Cunha Varolli, Rodrigo Luz   +7 more
doaj   +1 more source

An observational study to identify factors associated with readmission and to evaluate the impact of pharmacist validation of discharge prescriptions on readmission rate [PDF]

To identify demographic and pharmaceutical factors associated with readmission and to determine whether pharmacist validation of discharge prescriptions impacted on readmission rate in a district general hospital.
Culshaw, Margaret, Stephenson, John, Upton, Sarah   +2 more
core  

Pharmacists in Pharmacovigilance: Can Increased Diagnostic Opportunity in Community Settings Translate to Better Vigilance? [PDF]

, 2014
The pharmacy profession has undergone substantial change over the last two to three decades. Whilst medicine supply still remains a central function, pharmacist’s roles and responsibilities have become more clinic and patient focused.
AG Granas, AI Wertheimer, B Gray, C Gonzalez-Gonzalez, C Su, Christine Randall, Consumers’ Association, Consumers’ Association, Consumers’ Association, D Brown, D Stewart, David Brown, DM Ashcroft, E Horsley, E Kroger, E Richardson, G Marchildon, GD Lansam, JK Jesson, Justine Howard, K Grootheest van, KB Blake, L Emmerton, L Hanna, M Jadeja, M Rosenthal, M Tobaiqy, MA Hadi, MP Smith, N Black, N Iqbal, P Chan, P Gavaza, P Rutter, Paul Rutter, S Keyhani, SS Sardas, T Kimura, V Paudyal, Z Austin   +39 more
core   +1 more source