Results 81 to 90 of about 115,679 (313)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Pharmacist-led interventions to improve medication use and safety in older people who access hospital inpatient and aged care services

, 2017
Older people (over 65 years) are at increased risk of medication-related problems (MRPs) and adverse medication events compared with younger adults. Within the older population, there is a very high risk subgroup: those who access hospital inpatient and ...
Elliott, Rohan (3750754)
core   +1 more source

Risk factors for bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae

Brazilian Journal of Infectious Diseases, 2011
The objective of this study was to identify risk factors for bacteremia by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae.
Olivia Ferrández Quirante, PhD, PharmD, Santiago Grau Cerrato, PhD, PharmD, Sonia Luque Pardos, PhD, PharmD   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Use of the ONCO-TreC electronic diary compared with a standard paper diary to improve adherence to oral cancer therapy in patients with solid and haematological tumours: protocol for a randomised controlled trial

BMJ Open, 2022
Patrizia Serra, Carla Masini, Cecilia Anesi, Lorenzo Gios, Alessandro Passardi, Roberto Vespignani, Marco Dianti, Stefano Forti, Enrico Maria Piras, Claudio Eccher, Orazio Caffo, Annalisa Campomori, Erika Brugugnoli, Valeria Giardino, Elisabetta Petracci, Giulia Bartolini, Francesco Sullo, Valentina Oberosler   +17 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Impact of pharmaceutical care on self-administration of outpatient low-molecular-weight heparin therapy [PDF]

, 2014
Outpatient subcutaneous (s.c.) therapies are becoming more and more common in the treatmentof different diseases. The effectiveness of community-pharmacy-based interventions in preventingproblems that arise during s.c.
Kurt E. Hersberger, Hersberger, Kurt E., Tsakiris, Dimitrios A., Mittag, Michael, Seraina Mengiardi, Stephan Kraehenbuehl, Molnar, Viviane, Michael Mittag, Kraehenbuehl, Stephan, Dimitrios A. Tsakiris, Mengiardi, Seraina, Kohlhaas-Styk, Urs, Viviane Molnar, Urs Kohlhaas-styk   +13 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Synthesis and Preliminary Biological Activity Evaluation of New N- Substituted Phthalimide Derivatives

Iraqi Journal of Pharmaceutical Sciences, 2020
A A new series of bases of Schiff (H2-H4) derived from phthalic anhydrideweresynthesized. These Schiff bases were prepared by the reaction of different amines (tyrosine methyl ester, phenylalanine methyl ester, and isoniazid) with the phthalimide ...
Halah A. Sahib, Mohammed H. Mohammed
doaj   +1 more source