Results 71 to 80 of about 130,335 (313)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Use of the ONCO-TreC electronic diary compared with a standard paper diary to improve adherence to oral cancer therapy in patients with solid and haematological tumours: protocol for a randomised controlled trial

BMJ Open, 2022
Patrizia Serra, Carla Masini, Cecilia Anesi, Lorenzo Gios, Alessandro Passardi, Roberto Vespignani, Marco Dianti, Stefano Forti, Enrico Maria Piras, Claudio Eccher, Orazio Caffo, Annalisa Campomori, Erika Brugugnoli, Valeria Giardino, Elisabetta Petracci, Giulia Bartolini, Francesco Sullo, Valentina Oberosler   +17 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Study on the Effects of Chloroformic Extract of Securigera Securidaca on Serum Glucose Level and Liver Glycogen Content of Mice [PDF]

Journal of Kerman University of Medical Sciences, 2005
Although Securigera securidaca (Ss) has long been known for its hypoglycemic effect, the precise nature of its effective component(s) and the involved mechanisms have not been investigated yet.
S Zahedi-Asl, H Marahel, B Zaree
doaj  

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

A Smart mobile health intervention: Improving hypertension self-management through whatsapp-delivered video education [PDF]

BIO Web of Conferences
Hypertension remains a leading global health challenge, particularly in low-resource settings where access to health education is limited. This study aimed to evaluate the effectiveness of a video-based educational intervention delivered via WhatsApp in ...
Akhyar Zeda Kumala, Styawan Anita Agustina, Ghozali Muhammad Thesa   +2 more
doaj   +1 more source

Pharmacist working conditions [PDF]

Canadian Pharmacists Journal / Revue des Pharmaciens du Canada, 2016
I applaud the British Columbia College of Pharmacists for supporting an examination of pharmacist working conditions.1 This issue has been swept under the table for far too long, and it isn’t surprising to see that this study suggests that almost a third of pharmacists feel they are practising in an unsafe work environment. Almost 2 years ago, I had to
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source