Results 151 to 160 of about 186,636 (307)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Factors affecting task shifting/sharing from physicians to pharmacists in cancer chemotherapy in Japan: A qualitative study. [PDF]

PLoS One
Ikuta K, Yonezawa A, Okada H, Naganawa H, Sugimoto M, Ikemi Y, Saigo M, Manaka A, Terada T.   +8 more
europepmc   +1 more source

The Clinical Pharmacist [PDF]

Annals of Pharmacotherapy, 1967
openaire   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Range of cardiovascular medications dispensing practice without a prescription: A cross-section study on pharmacists at community pharmacies in Libya

Proper administration of medication for individuals with cardiovascular diseases requires critical actions. However, the irrational use of cardiovascular medications has increased.
Naeimah S. Sulayman Aboulqassim
core   +1 more source

Unlocking the full potential of pharmacists in the fight against non-communicable diseases

The Lancet Primary Care
Grace Grange, Amy Hai Yan Chan, Helena Rosado, Victoria Rutter   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

THE CONTRIBUTION OF NORTH DAKOTA'S COMMUNITY PHARMACIES TO THE STATE'S ECONOMY [PDF]

A pharmacist shortage, mail and internet competition, thinning margins, and third-party payer issues are some of the issues challenging community pharmacies.
Hodur, Nancy M., Leistritz, F. Larry
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Call for papers: strengthening primary care through integrated clinical pharmacy services-models, outcomes and implementation. [PDF]

Int J Clin Pharm
Nazar Z, Sahm L, Kallis T.
europepmc   +1 more source