Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Why we must say goodbye to 'clinical' pharmacists
This is the pre-peer-reviewed version of the following article: Khan N (2018), Why we must say goodbye to ‘Clinical’ Pharmacists, The Pharmaceutical Journal, vol 301 No 7951, which has been published in final form in print and also available at https ...
Khan, Nahim
core
What Deprescribing Information Should Be Communicated on Discharge and How? A Qualitative Study of Pharmacists' Perspectives on Deprescribing at Transitions of Care. [PDF]
Desforges K +7 more
europepmc +1 more source
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
How can community pharmacists support people living with eating disorders? identifying evidence gaps and practice opportunities in Australia. [PDF]
Mansour E +4 more
europepmc +1 more source
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Assessing the knowledge, attitude, and practice of Egyptian pharmacists on probiotics: a cross-sectional study. [PDF]
El Baghdady NS, Elmazar MM, Hamza MS.
europepmc +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Disposal of expired medicines in Jordan: Practices of community pharmacists. [PDF]
Hamed R +3 more
europepmc +1 more source

