Results 141 to 150 of about 181,985 (340)

Overcoming EGFR‐Mediated Dendritic Cell Dysfunction to Enhance Anti‐tumor Immunity in EGFR‐Mutant NSCLC by Precisely Targeting CD73 With pH‐responsive Nanocarriers

Advanced Science, EarlyView.
EGFR mutations drive ERK/c‐Jun–mediated transcriptional activation of CD73, elevating adenosine levels and fostering an immunosuppressive TME by impairing DC maturation and CD8⁺ T cell priming. The pH‐responsive nanodrug F127ZIF‐8AB680 selectively inhibits CD73, normalizes adenosine metabolism, and re‐establishes effective anti‐tumor immunity ...
Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, Yanguo Liu   +14 more
wiley   +1 more source

GWAS in interaction with childhood traumas implicates novel variants and genes previously associated with suicide-related factors in the background of suicidal ideation

European Psychiatry
Introduction Although suicide claims more lives than war and homicide, we still have no sufficient and effective methods either for its prediction or for its prevention.
X. Gonda, S. Krause, B. Erdelyi-Hamza, S. Sutori, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz, D. Torok   +8 more
doaj   +1 more source

Diflunisal: a review of pharmacokinetic and pharmacodynamic properties, drug interactions, and special tolerability studies in humans. [PDF]

, 1977
KF Tempero, VJ Cirillo, S L Steelman
openalex   +1 more source

Protein production is an early biomarker for RNA‐targeted therapies [PDF]

, 2018
Alex, Jacob, Barthélemy, Nicolas, Bateman, Randall J, Bollinger, James G, Cole, Tracy, Kordasiewicz, Holly B, Miller, Timothy M, Sato, Chihiro, Schoch, Kathleen M, Self, Wade K, Swayze, Eric   +10 more
core   +2 more sources

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, EarlyView.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source

The Pharmacokinetics and Pharmacodynamics of Atracurium in Patients with and without Renal Failure [PDF]

, 1984
Mark R. Fahey, Stephen M. Rupp, Dennis M. Fisher, Ronald D. Miller, Manohar Sharma, Claver Canfell, Kay Castagnoli, Pim J. Hennis   +7 more
openalex   +1 more source

Multispectral Chiral Quasi‐Bound States in the Continuum Enabled Microfluidics for High‐Throughput Molecular Screening and Quantification

Advanced Science, EarlyView.
A microfluidics‐integrated chiral quasi‐BIC metachip is developed that generates strong broadband CD from 0.5–2.0 THz in aqueous environments. A UMAP algorithm processes the resulting multidimensional CD features for simultaneous biomolecular conformation identification and concentration quantification (0.05–0.3 mg dL−1).
Xinyue Liang, Zihan Zhao, Xiaocong Tang, Haiyue Yang, Lanju Liang, Meng Zhao, Cong Wang, Lei Wang, Xumin Ding   +8 more
wiley   +1 more source

Soft Micromanipulation Robot for Real‐Time Adaptive Multimodal Operation

Advanced Science, EarlyView.
This manuscript proposes a soft micromanipulator robot (SMR) for “full‐angle” precision biomedical operations. Bio‐inspired SMR achieves omnidirectional motion, micrometer precision, and multimodal capabilities including aspiration, transfer, rotation, assembly, injection, and cutting.
Zhuowei Li, Xiaotian Lin, Zhoujie Zhu, Yibo Zhu, Yanping Zhou, Jing Li, Chris Gerada, He Zhang, Songlin Zhuang   +8 more
wiley   +1 more source

A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors. [PDF]

, 2015
BackgroundThis first-in-human study evaluated AMG 208, a small-molecule MET inhibitor, in patients with advanced solid tumors.MethodsThree to nine patients were enrolled into one of seven AMG 208 dose cohorts (25, 50, 100, 150, 200, 300, and 400 mg ...
Amore, Benny, Beaupre, Darrin M, Caudillo, Isaac, Deng, Hongjie, Fu, Siqing, Hong, David S, Hwang, Yuying C, Janku, Filip, Khan, Rabia, Kurzrock, Razelle, Lee, Peter, Loberg, Robert, Lockhart, A Craig, Ngarmchamnanrith, Gataree, Rosen, Peter   +14 more
core   +2 more sources

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source