Results 251 to 260 of about 181,985 (340)

Pharmacokinetic and Pharmacodynamic Interaction of Metformin and Ojeok-san in Healthy Volunteers. [PDF]

Drug Des Devel Ther
Lee S, Chae S, Kwon M, Shim WS, Lee KT, Yim SV, Kim BH.   +6 more
europepmc   +1 more source

Pharmacokinetic-pharmacodynamic (PK-PD) relationships of methadone and hydromorphone infusions in pain patients

, 1988
C E Inturrisi, Russell K. Portenoy, Mitchell B. Max, M. Stillman, Wayne A. Colburn, Kathleen M. Foley   +5 more
openalex   +1 more source

One‐Year Outcomes of Short‐Term Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Drug‐Eluting Stents: A Meta‐Analysis of Randomized Clinical Trials

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Dual antiplatelet therapy (DAPT) is recommended after percutaneous coronary intervention (PCI), though the optimal duration is unclear. DAPT reduces stent thrombosis, repeat myocardial infarction, and cardiovascular death, though at the cost of increased bleeding events.
Thomas Fretz, Srikiran Dasari, John Sakaleros, Abdul Mueez Alam Kayani, Nathaniel Bluckner, Kristina Pond, Nathan Markus, Alejandra Cardona‐Perez, Alan Garcia, Ricky Lemus‐Zamora, Jeffrey Breall   +10 more
wiley   +1 more source

Simultaneous Determination of the Pharmacokinetics and Pharmacodynamics of Chlorpromazine in the Brain of Mice

, 1986
Yukinobu Gotoh, Shinji Shibanoki, Koichi Ishikawa   +2 more
openalex   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Safety, tolerability, pharmacokinetics, immunogenicity and pharmacodynamics of 9MW1911, an anti-ST2 monoclonal antibody: results from a first-in-human phase 1 study. [PDF]

Front Pharmacol
Zhao Q, Li Q, Wang Y, Li L, Zhao X, Wu N, Fu D, Yin D, Feng J, Hu Z, Guo Y, Chen R.   +11 more
europepmc   +1 more source

Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders

ChemMedChem, EarlyView.
A partial proteolysis targeting chimera (PROTAC) library bearing achiral phenyl dihydrouracil cereblon ligands is prepared. It is then applied to the rapid development of a full PROTAC library targeting Bruton's tyrosine kinase, which can be directly used for screening.
Chelsi M. Almodóvar‐Rivera, Ira Tandon, Ramesh Mudududdla, Paulina N. Esguerra, Kevin Lucio‐Acero, Weiping Tang   +5 more
wiley   +1 more source

In memoriam: George L. Drusano. [PDF]

Antimicrob Agents Chemother
Arias CA.
europepmc   +1 more source

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, EarlyView.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source