Results 71 to 80 of about 101,624 (260)

The role of metabotropic glutamate receptor 7 (mGluR7) in drug dependence

Current Issues in Pharmacy and Medical Sciences, 2012
The successful pharmacotherapy for drug addiction is a challenge for pharmacology in XXI century. We still do not have any registered medication for cocaine by FDA, alcohol therapies are not enough successful. High hopes concern metabotropic glutamate 7
Małgorzata Jenda, Kinga Gaweł, Jolanta H. Kotlińska   +2 more
doaj   +1 more source

Is Gender an Important Factor in the Precision Medicine Approach to Levocetirizine?

Currently, there is insufficient information on the variability in levocetirizine pharmacometrics among individuals, a crucial aspect for establishing its clinical use.
Ji-Hun Jang, Yong-Bok Lee, Seung-Hyun Jeong   +2 more
core   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Betulinic acid ameliorates cast‐immobilized skeletal muscle atrophy but not denervation‐induced skeletal muscle atrophy

JCSM Communications
Background Terpenoids have gained attention as therapeutic agents for skeletal muscle atrophy owing to their various physiological activities. In this study, we screened four terpenoids for their therapeutic potential against muscle atrophy in cultured ...
Yuki Enoki, Yuki Kanezaki, Isamu Takahata, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
doaj   +1 more source

Pharmacokinetics and Pharmacodynamics of Ocular Drugs

, 2016
This chapter aims to provide the readers a systematic overview of the pharmacokinetics and pharmacodynamics of the drugs intended for ophthalmic use. The concepts of ocular pharmacokinetics and pharmacodynamics are briefly discussed in the introduction ...
Dave, Vivek S, Vivek S. Dave, Bhansali, Suraj G., Suraj G. Bhansali   +3 more
core   +1 more source

Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda. [PDF]

, 2006
BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack ...
Bajunirwe, Francis, Piola, P, Piola, Patrice, Taylor, W R J, Babigumira, J, Kyomuhendo, J, Taylor, Walter R. J., Checchi, Francesco, Babigumira, Joseph, Ruzagira, E, Kyomuhendo, Juliet, Taylor, Walter RJ, Ferradini, Laurent, Kiguli, James, Kiguli, J, Ferradini, L, Fogg, C, Fogg, Carole, Bajunirwe, F, Guthmann, J P, Ruzagira, Eugene, Biraro, S, Kigozi, Isaac, Checchi, F, Guthmann, Jean-Paul, Biraro, Samuel, Grandesso, Francesco, Grandesso, F, Kigozi, I, Kyomuhendo Juliet, Laurent Ferradini, Francis Bajunirwe, Walter RJ Taylor, Carole Fogg, Eugene Ruzagira, Isaac Kigozi, Taylor Walter RJ, Ruzagira Eugene, Biraro Samuel, Piola Patrice, Fogg Carole, Francesco Checchi, Samuel Biraro, Babigumira Joseph, Kigozi Isaac, James Kiguli, Grandesso Francesco, Joseph Babigumira, Kiguli James, Jean-Paul Guthmann, Ferradini Laurent, Patrice Piola, Guthmann Jean-Paul, Francesco Grandesso, Checchi Francesco, Juliet Kyomuhendo, Bajunirwe Francis   +56 more
core   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

The interictal transcriptomic map of migraine without aura

The Journal of Headache and Pain
Background The present study aimed to deliver a replicable transcriptomic map of migraine without aura (MO) and its comprehensive, genome- and drug discovery focused analysis to identify hypotheses for future research- and clinical attempts.
Peter Petschner, Sahel Kumar, Duc A. Nguyen, Dora Torok, Zsofia Gal, Daniel Baksa, Kinga Gecse, Gyongyi Kokonyei, Hiroshi Mamitsuka, Gabriella Juhasz   +9 more
doaj   +1 more source

An introduction to pharmacodynamics

, 2008
This article gives an overview of the principles of pharmacodynamics—the effect that drugs have on the body. A basic understanding of this aspect of pharmacology and in particular how drugs interact with the four main types of regulatory proteins ...
Simon Young, Arwel Thomas
core   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source