Results 91 to 100 of about 101,624 (260)
Current Issues in Pharmacy and Medical SciencesIn the present study, we investigated the mechanisms of cross-reinstatement of nicotine-induced place conditioning in rats. We used the conditioned place preference (CPP) paradigm and our data revealed that nicotine (0.175 mg/kg, base, i.p.) produced a ...
Barbara Budzyńska +3 more
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“Legal highs” – drugs of the twenty-first century
Current Issues in Pharmacy and Medical Sciences, 2012 "Legal highs" is a term that embraces many compounds, including plant substances and synthetic derivatives. Trends in the use of traditional drugs of abuse by young people, are downward.
Magdalena Różyło +2 more
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, 2016 Saed Abbasi,* Kazuaki Kajimoto,* Hideyoshi Harashima Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan *These authors contributed equally to this work Abstract: 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) has
Kajimoto K, Harashima H, Abbasi S
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Advanced Science, EarlyView.This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun +7 more
wiley +1 more source
Introduction to pharmacokinetics and pharmacodynamics
, 2016 Preceded by Introduction to pharmacokinetics and pharmacodynamics : the quantitative basis of drug therapy / Thomas N. Tozer, Malcolm Rowland. c2006.Includes index.pharmacy bookfair2016xii, 386 pages :Preceded by Introduction to pharmacokinetics and ...
Rowland, Malcolm, author. +1 more
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Advanced Science, EarlyView.Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang +6 more
wiley +1 more source
Advanced Science, EarlyView.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
wiley +1 more source
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
CPT: Pharmacometrics & Systems PharmacologyPyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur +3 more
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Advanced Science, EarlyView.AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan +13 more
wiley +1 more source