Results 81 to 90 of about 93,887 (308)

Pharmacokinetics and Pharmacodynamics of Ocular Drugs

, 2016
This chapter aims to provide the readers a systematic overview of the pharmacokinetics and pharmacodynamics of the drugs intended for ophthalmic use. The concepts of ocular pharmacokinetics and pharmacodynamics are briefly discussed in the introduction ...
Dave, Vivek S, Vivek S. Dave, Bhansali, Suraj G., Suraj G. Bhansali   +3 more
core   +1 more source

Unique Effects of (R)-Ketamine Compared to (S)-Ketamine on EEG Theta Power in Rats

Pharmaceuticals
Differences in the pharmacological effects of (S)-ketamine and (R)-ketamine are at the focus of research. Clinical data and our rat studies confirmed the antidepressant effect of (S)- but not (R)-ketamine, with similar differences in quantitative ...
Dóra Pothorszki, Szabolcs Koncz, Dóra Török, Noémi Papp, György Bagdy   +4 more
doaj   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, and Bioequivalence of Test Insulin Glargine Versus Reference Preparation (Lantus®) in Healthy Male Volunteers—By Euglycemic Clamp Technique

The aim of this study was to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), and safety of two insulin glargine preparations in healthy Chinese male subjects. Methods: Forty healthy Chinese male subjects were enrolled in this randomized, open,
Min Liu, Mingxue Zhu, Yi Tao, Zhongping Li, Hongtao Zhao, Chengyong Tang, Yuan Chen, Lei Wan   +7 more
core   +1 more source

An introduction to pharmacodynamics

, 2008
This article gives an overview of the principles of pharmacodynamics—the effect that drugs have on the body. A basic understanding of this aspect of pharmacology and in particular how drugs interact with the four main types of regulatory proteins ...
Simon Young, Arwel Thomas
core   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source

Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects

, 2015
Seonghae Yoon,1 Donghoon Shin,1 Howard Lee,1,2 In-Jin Jang,1 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul National University Hospital, 2Department of Transdisciplinary ...
Jang IJ, Shin D, Yoon S, Yu KS, Lee H
core  

Pharmacodynamics for Nursing Students

, 2020
A video primer on pharmacodynamics to introduce nursing students to the receptor theory for drug action, the difference between potency and efficacy, and how drugs are classified as agonists (full or partial) or antagonists (reversible or irreversible)
Lim, William/W.K.
core  

Pharmacodynamics of cannabinoids

, 2019
“Pharmacodynamics of cannabinoids “(i.e. a set of biological effects elicited in the living organism by interaction with its biochemical and biophysical functions up to the cellular level) is studied for a long time during both, physiological
Alexandra Sulcova*
core   +1 more source

Pharmacokinetics and pharmacodynamics of insulin analogs in special populations with type 2 diabetes mellitus [PDF]

, 2011
Candis M Morello1,21Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 2School of Pharmacy, University of California San Francisco, Veterans Affairs San Diego Healthcare System, San Diego, CA, USAIntroduction: The ...
Candis Morello, Morello, Candis M, Morello CM   +2 more
core   +1 more source