Results 221 to 230 of about 46,119 (273)
Some of the next articles are maybe not open access.
Annual Review of Medicine, 2010
Warfarin is a drug with a narrow therapeutic index and a wide interindividual variability in dose requirement. Because it is difficult to predict an accurate dose for an individual, patients starting the drug are at risk of thromboembolism or bleeding associated with underdosing or overdosing, respectively.
Kamali F, Wynne H
openaire +3 more sources
Warfarin is a drug with a narrow therapeutic index and a wide interindividual variability in dose requirement. Because it is difficult to predict an accurate dose for an individual, patients starting the drug are at risk of thromboembolism or bleeding associated with underdosing or overdosing, respectively.
Kamali F, Wynne H
openaire +3 more sources
Pharmacogenomics, 2010
Psoriasis is an inflammatory hyperproliferative skin disorder with a strong genetic predisposition. While many effective modalities are currently available for treating psoriasis, response to therapy is quite variable among patients. The genetic component underlying the response to pharmacotherapy in psoriasis is slowly beginning to emerge and ...
Darren D, O'Rielly, Proton, Rahman
openaire +2 more sources
Psoriasis is an inflammatory hyperproliferative skin disorder with a strong genetic predisposition. While many effective modalities are currently available for treating psoriasis, response to therapy is quite variable among patients. The genetic component underlying the response to pharmacotherapy in psoriasis is slowly beginning to emerge and ...
Darren D, O'Rielly, Proton, Rahman
openaire +2 more sources
Introduction to pharmacogenetics
Drug and Therapeutics Bulletin, 2023There is considerable interindividual variability in the effectiveness and safety of medicines. Although the reasons for this are multifactorial, it is well recognised that genetic changes impacting the absorption or metabolism of these drugs play a significant contributory role.
John Henry, McDermott, William, Newman
openaire +2 more sources
Current Opinion in Psychiatry, 2019
Purpose of review The implementation of pharmacogenetic testing in psychiatry is underway but is not yet standard protocol. Barriers to pharmacogenetics becoming standard practice are the lack of translation of evidence-based recommendations and ...
C. Bousman, A. Maruf, D. Müller
semanticscholar +1 more source
Purpose of review The implementation of pharmacogenetic testing in psychiatry is underway but is not yet standard protocol. Barriers to pharmacogenetics becoming standard practice are the lack of translation of evidence-based recommendations and ...
C. Bousman, A. Maruf, D. Müller
semanticscholar +1 more source
Pharmacogenetics in Psychiatry
2018Mental illness represents a major health issue both at the individual and at the socioeconomical level. This is partly due to the current suboptimal treatment options: existing psychotropic medications, including antidepressants, antipsychotics, and mood stabilizers, are effective only in a subset of patients or produce partial response and they are ...
Corponi, Filippo +2 more
openaire +2 more sources
2018
Pharmacogenetics is the study of how genetics influences drug treatment outcomes. Much research has been conducted to identify and characterize gene variants that impact the pharmacokinetic and pharmacodynamic aspects of medications used to treat neurologic and psychiatric disorders.
openaire +2 more sources
Pharmacogenetics is the study of how genetics influences drug treatment outcomes. Much research has been conducted to identify and characterize gene variants that impact the pharmacokinetic and pharmacodynamic aspects of medications used to treat neurologic and psychiatric disorders.
openaire +2 more sources
Pharmacogenetics and Psychiatry
Current Psychiatry Reports, 2004Genetic factors play a significant role in predicting an individual's response to a drug. The response may be the desired therapeutic effect of the drug and also may be the undesirable development of adverse effects. This relationship between genes and drug response interests the pharmacogeneticist. This article aims to give an overview of the exciting
Basu, A, Tsapakis, E, Aitchison, K
openaire +3 more sources
Pharmacogenetics and the Fetus
New England Journal of Medicine, 1982It is well accepted in clinical medicine that there is wide variation between patients in the handling of and response to drugs; these differences are based in part on genetic mechanisms. Pharmacogenetic differences among patients contribute to altered drug kinetics, resulting in failure of therapy or in side effects related to blood levels after ...
openaire +2 more sources
Vestnik oftal'mologii, 2019
In recent years, β-adrenergic blockers have become the first choice drugs for glaucoma treatment. Timolol holds the main position among them, being a part of most combined antiglaucoma preparations. The use of timolol maleate in clinical practice may be accompanied by severe side effects affecting different organs and systems.
L K, Moshetova +3 more
openaire +2 more sources
In recent years, β-adrenergic blockers have become the first choice drugs for glaucoma treatment. Timolol holds the main position among them, being a part of most combined antiglaucoma preparations. The use of timolol maleate in clinical practice may be accompanied by severe side effects affecting different organs and systems.
L K, Moshetova +3 more
openaire +2 more sources
Depression and Pharmacogenetics
Archives of Psychiatric Nursing, 2018Depression is the most common and leading devastating psychiatric illness that affects a majority of the world population. The treatment of depression has been a challenge for a majority of patients and healthcare practitioners. The advent of pharmacogenomics (PGx) empowered the Food and Drug Administration to approve some antidepressant biomarkers for
openaire +2 more sources