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The Clinical Pharmacogenetics Implementation Consortium: 10 Years Later
Clinical pharmacology and therapy, 2019 In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www.cpicpgx.org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB, http://www.pharmgkb.org) and the National Institutes of Health (NIH), was created to provide ...
M. Relling +5 more
semanticscholar +1 more source
Pharmacogenetics in Clinical Practice
Prague Medical Report, 2012 Pharmacogenetics is a discipline that investigates how genetic variation relates to the drug efficacy and safety. The goal of pharmacogenetics is a personalized treatment, where according to genotype we would be able to prescribe the most effective drug ...
Hana Bakhouche, O. Slanař
doaj +1 more source
The role of pharmacogenetics in keloid scar treatment: A literature review
Scars, Burns & Healing, 2020 Background: The pathophysiology of keloid scars is still not fully understood and a universally reliable effective treatment has not been identified. Pharmacogenetics explores how drug response to a particular therapy can relate to genetic variations ...
Tamara Searle +2 more
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Introduction : biofutures/biopresents [PDF]
, 2006 Two very different reports produced for the UK government in the last three years have connected the state of our physical health with that of our material wealth. The first of these was produced in 2003 by the Bioscience Innovation and Growth Team (BIGT)
Birch, Kean
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Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals [PDF]
, 2017 In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because ...
Caputo, Mariela +4 more
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BMC Cancer, 2019 Background High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach ...
Stefanie Klenke +5 more
doaj +1 more source
Pharmacogenetics and individualizing drug treatment during pregnancy [PDF]
, 2014 Pharmacogenetics as a tool to aid clinicians implement individualized pharmacotherapy is utilized in some areas of medicine. Pharmacogenetics in pregnancy is still a developing field.
Haas, David M.
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Systematic identification of non-coding pharmacogenomic landscape in cancer
Nature Communications, 2018 In this study the authors build lncRNA-drug response models for 265 anti-cancer agents across 27 cancer types. They report their cancer cell line based lncRNA EN-models are able to effectively predict therapeutic outcome for breast cancer, ovarian cancer,
Yue Wang +6 more
doaj +1 more source
Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]
, 2016 Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R. +7 more
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European Journal of Human Genetics, 2019 Despite advances in the field of pharmacogenetics (PGx), clinical acceptance has remained limited. The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize ...
C. Lunenburg +14 more
semanticscholar +1 more source