Results 91 to 100 of about 599,269 (342)

Effect of Renal Impairment on Pharmacokinetics and Safety of Ensitrelvir, a SARS-CoV-2 3CL Protease Inhibitor

Infectious Diseases and Therapy
Introduction Ensitrelvir, a novel oral inhibitor of 3C-like protease of SARS-CoV-2, shows efficacy and safety in participants with mild to moderate COVID-19.
Takayuki Katsube, Safwan Kezbor, Ryosuke Shimizu, Ryuji Kubota   +3 more
doaj   +1 more source

Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model

Clinical and Translational Science, 2020
In the development of new drugs, the prediction of metabolite‐to‐parent plasma exposure ratio in humans prior to administration in a clinical study has emerged as an important need.
Ernesto Callegari, Manthena V.S. Varma, R. Scott Obach   +2 more
doaj   +1 more source

Semiconducting Polymer Nanoparticles as Multimodal Agents for Optical and Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Semiconducting polymer nanoparticles (SPNs) exhibit many advantageous optical and biological properties. Multimodal SPN‐based contrast agents that integrate several imaging modalities yield a wealth of information through the use of different imaging mechanisms.
Faysal A. Farah, Yu Qin, Mark A. Green, James D. E. T. Wilton‐Ely   +3 more
wiley   +1 more source

Pharmacokinetics of gamithromycin in pigs [PDF]

, 2012
Objectives : Gamithromycin, a 15-membered semi-synthetic macrolide antibiotic of the azalide subclass, has recently been developed for the treatment and prevention of bovine respiratory disease (BRD).
Croubels, Siska, De Backer, Patrick, De Baere, Siegrid, Meyer, Evelyne, Plessers, Elke, Watteyn, Anneleen, Wyns, Heidi   +6 more
core   +1 more source

Sexual enhancement products for sale online : raising awareness of the psychoactive effects of Yohimbine, Maca, Horny Goat Weed and Ginkgo Biloba [PDF]

, 2014
Copyright © 2014 Ornella Corazza et al.This is an open access article distributed under theCreativeCommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Eleonora Chillemi, Fabrizio Schifano, Giovanni Martinotti, Massimo Di Giannantonio, Ornella Corazza, Rita Santacroce, Selim Cellek   +6 more
core   +4 more sources

Advanced Oral Delivery Systems for Nutraceuticals

Advanced Healthcare Materials, EarlyView.
Emerging delivery technologies are explored to overcome barriers to oral nutraceutical absorption. Traditional carriers are compared with novel platforms including biodegradable polymers, MOFs, MPNs, and 3D printing. These systems enhance bioavailability, control release, and enable personalized nutrition.
Xin Yang, Linzixuan Zhang, Zhiling Zheng, Robert Langer, Ana Jaklenec   +4 more
wiley   +1 more source

Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions

CPT: Pharmacometrics & Systems Pharmacology
Pyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur, Sumathy Mathialagan, Emi Kimoto, Manthena V. S. Varma   +3 more
doaj   +1 more source

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

Nature Communications, 2018
REV-ERBα is a nuclear receptor that links the circadian pathways with those of metabolism. Here the authors show REV-ERBα is also involved with linking the circadian system with the inflammatory pathways of an experimental model of colitis through ...
Shuai Wang, Yanke Lin, Xue Yuan, Feng Li, Lianxia Guo, Baojian Wu   +5 more
doaj   +1 more source

In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. [PDF]

, 2018
BackgroundLiver disease (LD) prolongs mirtazapine half-life in humans, but it is unknown if this occurs in cats with LD and healthy cats.Hypothesis/objectivesTo determine pharmacokinetics of administered orally mirtazapine in vivo and in vitro (liver ...
Benson, Kellyi K, Fitzpatrick, Rikki L, Gustafson, Daniel L, Quimby, Jessica M, Ramirez, Dominique, Sieberg, Liberty G, Wittenburg, Luke A   +6 more
core  

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source