Results 101 to 110 of about 219,082 (266)

On separation of time scales in pharmacokinetics [PDF]

arXiv, 2012
A lot of criticism against the standard formulation of pharmacokinetics has been raised by several authors. It seems that the natural reaction for that criticism is to comment it from the point of view of the theory of conservation laws. Simple example of balance equations for the intravenous administration of drug has been given in 2011 and the ...
arxiv  

Stable Radical Polymers as New Electroactive Materials: Synthesis, Properties, and Emerging Applications

Advanced Functional Materials, EarlyView.
This review covers the recent advances in the synthesis and properties of stable radical polymers (SRPs) and presents their applications in electronics, magnetics, optoelectronics, and biomedicines. The review concludes with a discussion of the challenges in radical chemistry and functionalization, while shedding light on the groundbreaking potential ...
Yufeng Xiong, Yingjiang Li, Xinfang Cui, Shiwei Li, Xiangdong Peng, Yanyun Ju, Tong Zhou, Rui Feng, Yang Zhang, Zehong Wang, Qing Wang, Lijie Dong   +11 more
wiley   +1 more source

Nonparametric estimation of a mixing distribution for a family of linear stochastic dynamical systems [PDF]

arXiv, 2015
In this paper we develop a nonparametric maximum likelihood estimate of the mixing distribution of the parameters of a linear stochastic dynamical system. This includes, for example, pharmacokinetic population models with process and measurement noise that are linear in the state vector, input vector and the process and measurement noise vectors.
arxiv  

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]

, 2010
The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed.
Anna-Lena Ungell, Bauer, Britt-Marie Fihn, Constanze Hilgendorf, Englund, Harrison, Iain S. Haslam, Johan E. Karlsson, Lam, Nicholas L. Simmons, Noe, Read, Simon Lowes   +12 more
core   +2 more sources

Ultra‐Effective Light‐Activated Antibacterial Activity via Carboxyl Functionalized Graphene Quantum Dots and Films

Advanced Functional Materials, EarlyView.
Carboxyl‐functionalized graphene quantum dots (cGQDs) exhibit high singlet oxygen quantum yield due to strong spin–orbit coupling. cGQDs achieve minimum bactericidal concentration of only 0.4 µg mL−1 against S. aureus under low‐intensity illumination.
Muhammad Hassnain, Laure S. van Hofwegen, Humeyra Nur Kaleli, Temirlan Kubanaliev, Zafer Eroglu, Asim Onal, Payal P. S. Balraadjsing, Onder Metin, Fahri Alkan, Sebastian A. J. Zaat, Sedat Nizamoglu   +10 more
wiley   +1 more source

Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model

Clinical and Translational Science, 2020
In the development of new drugs, the prediction of metabolite‐to‐parent plasma exposure ratio in humans prior to administration in a clinical study has emerged as an important need.
Ernesto Callegari, Manthena V.S. Varma, R. Scott Obach   +2 more
doaj   +1 more source

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken [PDF]

, 2018
Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear ...
A Pedretti, AM Haritova, C Issa, CH Nightingale, D Carvalho, D Osguthorpe, D Sadowski, E Abu-Basha, E Chieli, H Elsheikh, J Dupuy, J Formica, J Sugatani, J Yang, JS Choi, JS Choi, K Lohner, K Yamaoka, KJ Livak, L Gibellini, L Li, LR Fortunato, M Goliomytis, M Guo, M Guo, M Nair, MD Hanwell, MM Pulido, MP Nair, MR Durk, O Trott, P Zakeri-Milani, P Zakeri-Milani, PV Balimane, R Walker, S Borska, S Kim, S Wang, SL Hsiu, T Guo, T Guo, TT Cushnie, V Madgula, W Li, X Liu, Y Hee Choi, YJ Chae, YQ Shan, Z Chen   +48 more
core   +2 more sources

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, EarlyView.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]

, 2019
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source