Results 121 to 130 of about 599,269 (342)
The Aggravation of Clozapine-Induced Hepatotoxicity by Glycyrrhetinic Acid in Rats
Journal of Pharmacological Sciences, 2014 Clozapine (CLZ) was reported to be associated with hepatotoxicity. Glycyrrhetinic acid (GA) has a liver protective effect. Our preliminary experiments showed that GA aggravated rather than attenuated CLZ-induced hepatotoxicity in primary cultured rat ...
Ling-ling Jia +12 more
doaj
Pathophysiologic and pharmacokinetic determinants of the antihypertensive response to propranolol [PDF]
, 1977 Murray Esler +3 more
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Advanced Healthcare Materials, EarlyView.Molecule 2, which contains a shorter oligoether chain, binds to tamoxifen via structural similarity forming micelles with a positive surface charge, thereby enhancing cellular uptake. These fluorescent micelles induce lipid droplet (LD) accumulation, exhibit strong fluorescence, and effectively overcome tamoxifen resistance by synergizing with orlistat‐
Jung Yeon Park +4 more
wiley +1 more source
Clazepam: pharmacokinetics and effects on performance. [PDF]
, 1978 Giudicelli Jf +3 more
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Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma
Advanced Healthcare Materials, EarlyView.A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li +8 more
wiley +1 more source
Scientific Reports, 2017 Adriamycin (ADR) induces the over-expression of P-glycoprotein (P-gp) and multiple drug resistance in breast cancer cells. However, the biochemical process and underlying mechanisms are not clear.
Chun Ge +8 more
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Pediatric Obesity: Influence on Drug Dosing and Therapeutics [PDF]
, 2018 Obesity is an ongoing global health concern and has only recently been recognized as a chronic disease of energy homeostasis and fuel partitioning. Obesity afflicts 17% of US children and adolescents.
Ameer, Barbara, PharmD, MBA, BCPS, FCP +1 more
core +1 more source
Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery
Advanced Healthcare Materials, EarlyView.This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo +3 more
wiley +1 more source
Active CNS delivery of oxycodone in healthy and endotoxemic pigs
Fluids and Barriers of the CNSBackground The primary objective of this study was to advance our understanding of active drug uptake at brain barriers in higher species than rodents, by examining oxycodone brain concentrations in pigs.
Frida Bällgren +7 more
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Self Poisoning with Dieldrin: A Case Report and Pharmacokinetic Discussion [PDF]
, 1974 Andy Black
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