Results 151 to 160 of about 628,142 (342)

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Fluids and Barriers of the CNS
Background The primary objective of this study was to advance our understanding of active drug uptake at brain barriers in higher species than rodents, by examining oxycodone brain concentrations in pigs.
Frida Bällgren, Tilda Bergfast, Aghavni Ginosyan, Jessica Mahajan, Miklós Lipcsey, Margareta Hammarlund-Udenaes, Stina Syvänen, Irena Loryan   +7 more
doaj   +1 more source

Erratum to: A new approach to the compartmental analysis in pharmacokinetics: fractional time evolution of diclofenac [PDF]

, 2010
Jovan Popović, Milica Atanacković Krstonošić, Ana Pilipović, Milan R. Rapaić, Stevan Pilipović, Teodor M. Atanacković   +5 more
openalex   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Population Pharmacokinetic Modelling and Simulation of Anlotinib in Chinese Pediatric Patients with Advanced Soft Tissue Sarcomas [PDF]

Yifei Xue, Shuo Feng, Sixuan Zhao, Weiling Zhang, Jing Li, Tian Zhi, Chuhan Wu, Qiuju Guo, Lu Sun, Dongsheng Huang, Chao Zhang   +10 more
openalex   +1 more source

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

Advanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu, Qiang Long, Yihao Liu, Xiuqiao Sun, Baoding Zhang, Binxin Liao, Weibin Wu, Wangxi Hai, Pei Zhang, Wenhua Lian, Yuewen Zhu, Zheng Wang, Caisheng Wu, Xianming Deng, Hélder A. Santos, Xiaofeng Ye   +15 more
wiley   +1 more source

Optimizing antenatal corticosteroid therapy for improving outcome of premature infants. [PDF]

, 2019
A Donaldson, Augusto F. Schmidt, CL Elliott, D Roberts, E Asztalos, EP Davis, F Althabe, F Waffarn, GC Liggins, GC Liggins, HG Liley, JP Vogel, Kristi L. Watterberg, M Della Torre, P Ballabh, Philip L. Ballard, PL Ballard, PL Ballard, RS Egerman, SE Tsuei   +19 more
core   +1 more source

Pharmacokinetic variables and bioavailabiljty from muscle of creatine kinase in cattle [PDF]

, 1994
Hervé Lefèbvre, Pierre‐Louis Toutain, Jean-Paul Serthelon, Véronique Lassourd, L. Gardey, Jean‐Pierre Braun   +5 more
openalex   +1 more source

Figure S3 from Pharmacokinetics and Pharmacodynamics-Based Mathematical Modeling Identifies an Optimal Protocol for Metronomic Chemotherapy

, 2023
Joseph Ciccolini, Dominique Barbolosi, Christophe Meille, Aurélie Lombard, Cindy Serdjebi, Sarah Giacometti, Laëtitia Padovani, Eddy Pasquier, Nicolás André   +8 more
openalex   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source