Results 181 to 190 of about 323,413 (255)

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Correction to "A Phase 1 Study Evaluating the Pharmacokinetics and Safety of Avacopan in Participants With End-Stage Kidney Disease on Hemodialysis". [PDF]

J Clin Pharmacol
europepmc   +1 more source

Comparison of Beiyi^® and its reference product Enantone^® as agonists of luteinizing hormone-releasing hormone against prostate cancer: a multicenter, randomized single-dose study. [PDF]

Front Pharmacol
Yi Y, Shen P, Zheng T, Hou R, Fan L, Yu Y, Li J, Fang Y, Hao C, You P, Lu X, Lu X, Wei Q, Feng P.   +13 more
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Human Pharmacokinetic Prediction of Antibody-Drug Conjugates Using Human FcRn Transgenic Mice. [PDF]

Clin Transl Sci
Nakagawa K, Haraya K.
europepmc   +1 more source

Population pharmacokinetics of ritonavir-boosted atazanavir in subsequent-line treatment in African children with HIV. [PDF]

Antimicrob Agents Chemother
van Dyk J, Waitt C, Mugerwa H, Wiesner L, Orrell C, Bamford A, Gibb DM, McIlleron HM, Colbers A, Burger DM, Denti P, Wasmann RE.   +11 more
europepmc   +1 more source

The Potential of Selective COX-2 Inhibitor Mavacoxib for Extended Analgesia in Sheep Husbandry. [PDF]

Animals (Basel)
Fioretto O, Metcalf L, Lomax S.
europepmc   +1 more source

Pharmacokinetics of Fentanyl and Norfentanyl in a Rat Model of Fixed-Volume Hemorrhagic Shock. [PDF]

Eur J Drug Metab Pharmacokinet
Stach P, Skowron K, Rojek S, Cios A, Wesołowska A, Huestis MA, Gil K.   +6 more
europepmc   +1 more source

Renal-clearable fluorescent probe for early detection of pancreatic cancer in living murine models. [PDF]

Sci Adv
Huang M, Zhou Z, Zhang T, Xia X, Chen W, Wang E, Wang F, Ren J.   +7 more
europepmc   +1 more source