Results 201 to 210 of about 323,413 (255)
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Pharmacokinetics in the elderly
European Journal of Clinical Pharmacology, 1975The pharmacokinetics of sulphamethizole, paracetamol and phenylbutazone were investigated and compared in young and geriatric subjects. The rate and extent of absorption of the drugs did not appear to be affected by increasing subject age. However, the mean half-lives for sulphamethizole and paracetamol were significantly increased in the geriatric ...
E J, Triggs +3 more
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Journal of Neurology, 2010
This paper reviews the clinically relevant determinants of levodopa peripheral pharmacokinetics and main observed changes in the levodopa concentration-effect relationship with Parkinson's disease (PD) progression. Available clinically practical strategies to optimise levodopa pharmacokinetics and pharmacodynamics are briefly discussed.
Manuela, Contin, Paolo, Martinelli
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This paper reviews the clinically relevant determinants of levodopa peripheral pharmacokinetics and main observed changes in the levodopa concentration-effect relationship with Parkinson's disease (PD) progression. Available clinically practical strategies to optimise levodopa pharmacokinetics and pharmacodynamics are briefly discussed.
Manuela, Contin, Paolo, Martinelli
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International Journal of Gynecology & Obstetrics, 1990
The main types of pharmacologic therapy used to treat the hormone deficiency of menopause are parenteral and oral administrations of estrogen. Parenteral administration results in predictable absorption without major intermediary metabolism, whereas all oral estrogens are subject to intestinal metabolism before entering the systemic circulation ...
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The main types of pharmacologic therapy used to treat the hormone deficiency of menopause are parenteral and oral administrations of estrogen. Parenteral administration results in predictable absorption without major intermediary metabolism, whereas all oral estrogens are subject to intestinal metabolism before entering the systemic circulation ...
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American Heart Journal, 1983
The single-dose pharmacokinetics of amiodarone have been studied in volunteer subjects given 400 mg doses by the intravenous and oral routes. The data show the compound to have a very large volume of distribution, a low total clearance, and a long and variable terminal elimination half-life.
D W, Holt +3 more
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The single-dose pharmacokinetics of amiodarone have been studied in volunteer subjects given 400 mg doses by the intravenous and oral routes. The data show the compound to have a very large volume of distribution, a low total clearance, and a long and variable terminal elimination half-life.
D W, Holt +3 more
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Seminars in Hematology, 2001
Despite the clinical use of deferoxamine for more than a quarter of a century, pharmacokinetic studies are few and have not been performed explicitly in patients with sickle cell disorders. Early studies with Intravenous administration to healthy volunteers and patients with transfusional overload showed that although peak concentrations of ...
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Despite the clinical use of deferoxamine for more than a quarter of a century, pharmacokinetic studies are few and have not been performed explicitly in patients with sickle cell disorders. Early studies with Intravenous administration to healthy volunteers and patients with transfusional overload showed that although peak concentrations of ...
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Pharmacokinetics of amoxicillin
Clinical Pharmacology & Therapeutics, 1974Amoxicillin, a new semisynthetic penicillin, was administered in 250‐mg doses intravenously and orally to normal men. After intravenous doses, the mean alpha disposition constant was 3.994 hr‐1 and the mean beta disposition constant was 0.692 hr‐1 with a corresponding beta half‐life of 1.05 hr. The serum clearance rate was 0.264 1.kg‐1 with a volume of
D, Zarowny +4 more
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Pharmacokinetics and Immunotoxicity
1980The possibilities of different actions of xenobiotics on the immunological system are described (different cells with immunocompetence in distinct stages of development, indirect action, pharmacokinetics and especially biotransformation). Results concerning the toxic action and biotransformation are given for DOTC. The atrophy of the thymus produced by
P, Lange, G, Hennighausen, U, Karnstedt
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Pharmacokinetics and pregnancy
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1983In the last decades it has become clear that the effects of a drug in animals and in humans depend not only upon the dose of the drug, its intrinsic activity and the sensitivity of the end organs, but also on the disposition of the substance in the organism.
M C, Bogaert, M, Thiery
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The pharmacokinetics of pyridostigmine
Neurology, 1976A simplified gas chromatographic method for measuring quaternary ammonium compounds has been developed and used to measure the serum concentration of pyridostigmine in human beings. Pyridostigmine is present in the serum within 1 hour after oral administration and reaches a peak at 2 hours.
S L, Cohan +3 more
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The American Journal of Medicine, 1986
The pharmacokinetics of terazosin have been assessed in human volunteers, hypertensive patients, a limited number of elderly volunteers, and a small number of patients with congestive heart failure. Terazosin was administered intravenously and orally in doses ranging up to 7.5 mg.
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The pharmacokinetics of terazosin have been assessed in human volunteers, hypertensive patients, a limited number of elderly volunteers, and a small number of patients with congestive heart failure. Terazosin was administered intravenously and orally in doses ranging up to 7.5 mg.
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