Results 211 to 220 of about 496,699 (309)

Development of a Pregnancy-Specific Physiologically Based Pharmacokinetics (PBPK) Model for Aspirin. [PDF]

CPT Pharmacometrics Syst Pharmacol
Collins-Smith A, Kammala AK, Phelps MA, Wang XM, Menon R, Costantine MM.   +5 more
europepmc   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Correction: Pharmacokinetics and nephrotoxicity of cisplatin modulated by combination therapy with brusatol. [PDF]

Front Pharmacol
Guo N, Zhang Y, Yuan G, Zhang X, Zhang W, Wen Q.   +5 more
europepmc   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Correction: Population Pharmacokinetics Analysis of Infliximab in up to 10‑Year‑Old Patients with Paediatric Inflammatory Bowel Disease: Label‑Recommended Dose Fails to Achieve Therapeutic Target Concentration. [PDF]

Clin Pharmacokinet
Zhao Q, Jongsma MME, Vuijk SA, de Winter BCM, Martinez-Vinson C, Kolho KL, Norsa L, Hussey S, Wine E, Cohen S, Shouval DS, Assa A, Lev-Tzion R, de Meij T, Wolters VM, Huynh HQ, Preijers T, de Ridder L.   +17 more
europepmc   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Ligand-dependent pharmacokinetic modulation via copper doping in ultrasmall gold nanoparticles. [PDF]

Mater Today Bio
Gong J, Tian J, Wang N, Huang D, Liu Y, Tang B.   +5 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Vasopressor Strategy in Pediatric Sepsis: A Clinical Pharmacology Perspective. [PDF]

J Pediatr Pharmacol Ther
Green DJ, Watt KM.
europepmc   +1 more source

Pharmacokinetics of FK 506: Preclinical and clinical studies [PDF]

, 1990
Cadoff, E, Fung, JJ, Imventarza, O, Iwasaki, K, Jain, A, Krajack, A, Nagase, K, Starzl, TE, Todo, S, Venkataramanan, R, Warty, V   +10 more
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