Results 241 to 250 of about 599,269 (342)

Studies on absorption, distribution, metabolism, and excretion of a new macrolide antibiotic, SF-837. II. Pharmacokinetic studies on SF-837, M1, and M2 substances.

, 1974
Tomoko Shomura, Koshiro Umemura
openalex   +2 more sources

Analgesic Action and Pharmacokinetics of Morphine and Diazepam in Man [PDF]

, 1979
Jian Yang, W. Crawford Clark, S. H. Ngai, Barry A. Berkowitz, Sydney Spector   +4 more
openalex   +1 more source

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

Advanced Science, EarlyView.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang, Wengui Lu, Zhifei Cheng, Luyao Wang, Zhenzhen Jiang, Yike Yue, Pengyu Jiang, Zehua Xia, Lei He, Fengying Wang, Limin Wu, Qi Wang, Hui Han   +12 more
wiley   +1 more source

PHARMACOKINETIC STUDIES ON THE HEPATO-TOXICITY OF LUTEOSKYRIN (II)EXTRACTION AND IDENTIFICATION OF 3H-LUTEOSKYRIN FROM THE LIVER AND EXCRETA IN MICE

, 1975
Ikuko Ueno
openalex   +1 more source

Pharmacokinetics of fentanyl [PDF]

Anaesthesia, 1986
openaire   +3 more sources

STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis

Advanced Science, EarlyView.
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Tao   +7 more
wiley   +1 more source

High-Fat Meal Increase Blonanserin Bioavailability 5-Fold in Chinese Healthy Subjects. [PDF]

Drug Des Devel Ther
Sun X, Song H, Zhao N, Qiu B, Ding C, Wu H, Bai W.   +6 more
europepmc   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Urine Data Analysis for Pharmacokinetics of Aminopyrine and Its Metabolites in Man

, 1974
TAMOTSU KOIZUMI, Michihiro Ueda, SEIICHI TAKADA   +2 more
openalex   +2 more sources

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Advanced Science, EarlyView.
Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long, Borui Tang, Fei Xie, Lianqi Liu, Yangyihua Zhou, Jingwen Dong, Jianfeng Wang, Cuicui Sun, Yuting Wang, Ruoqi Li, Na Zhang, Liping Li, Longlong Luo, Junhai Xiao, Wu Zhong, Dian Xiao, Hongbin Deng, Xinbo Zhou   +17 more
wiley   +1 more source