Results 281 to 290 of about 599,269 (342)

Effect of Rifampicin on the Pharmacokinetics of Valemetostat and Its Primary Metabolite: A Phase 1 Study in Healthy Participants. [PDF]

Clin Transl Sci
Tachibana M, Matsuki S, Kurata A, Fukae M, Shinohara S, Shimizu T.   +5 more
europepmc   +1 more source

A Systematic Computational Framework for Practical Identifiability Analysis in Mathematical Models Arising from Biology

Advanced Science, EarlyView.
A systematic computational framework is developed for practical identifiability analysis in biological models. The framework establishes a rigorous definition, introduces efficient coordinate‐based identifiability metrics, and proposes novel regularization strategies.
Shun Wang, Wenrui Hao
wiley   +1 more source

Pharmacokinetics and Tissue Distribution of Palmatine after Single Intramuscular Injection in Partridge Shank Chickens. [PDF]

Vet Med Sci
Chen C, A-Ga YBM, Kuang X, Li Y, Xiang R, Liang J.   +5 more
europepmc   +1 more source

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source

Drug Transporters and Metabolizing Enzymes in Antimicrobial Drug Pharmacokinetics: Mechanisms, Drug-Drug Interactions, and Clinical Implications. [PDF]

Biomolecules
Lin K, Wang R, Li T, Zuo Y, Yang S, Dong D, Zhu Y.   +6 more
europepmc   +1 more source

Microwave‐Activated Bacterial Biorobot for Multimodal Cancer Therapy

Advanced Science, EarlyView.
An Escherichia coli bacterial biorobot is engineered for localized microwave activation in cancer therapy. Upon activation at tumor sites, the biorobot releases glucose oxidase, inducing tumor cell death via glucose depletion and H2O2 generation catalyzed by Cu2O.
Huilan Zhuang, Yongjian Zhang, Yajuan Fu, Dangjin Ke, Qi Chen, Sijie Shao, Panpan Xue, Yuanchun Chen, Xuemei Zeng, Shuangqian Yan   +9 more
wiley   +1 more source

Q‐GEM: Quantum Chemistry Knowledge Fusion Geometry‐Enhanced Molecular Representation for Property Prediction

Advanced Science, EarlyView.
This work introduces E‐GeoGNN, a graph neural network framework that systematically encodes molecular structural information through three hierarchical correlation graphs: atom‐bond graph, bond‐angle graph, and angle‐dihedral graph. By incorporating quantum and geometric dual‐scale self‐supervised pretraining, Q‐GEM is proposed, a novel molecular ...
Zhijiang Yang, Liangliang Wang, Tengxin Huang, Yunfan Wang, Mingchi Gao, Tingjun Hou, Junjie Ding, Junhua Xiao   +7 more
wiley   +1 more source

Influence of bodyweight on prednisolone pharmacokinetics in dogs. [PDF]

PLoS One
Purcell BL, Woodward AP, Leeming MG, Dandrieux JRS.   +3 more
europepmc   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

Pharmacokinetics and safety evaluation of anemoside B4 in healthy Beagle dogs. [PDF]

Front Vet Sci
Ji J, Ma Y, Wan S, Ding X, Wang J, Zhong Y, Song Y, Zhao J, Su Z, Jia K, Li S.   +10 more
europepmc   +1 more source