Results 41 to 50 of about 323,413 (255)

Novel Approach for the Approximation of Vitamin D3 Pharmacokinetics from In Vivo Absorption Studies

, 2023
The changing environment and modified lifestyles have meant that many vitamins and minerals are deficient in a significant portion of the human population.
Grzegorz Żurek, Magdalena Przybyło, Marek Langner, Wojciech Witkiewicz   +3 more
core   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Population pharmacokinetics of asciminib in tyrosine kinase inhibitor-treated patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic and acute phases

, 2022
Background: Asciminib, a first-in-class highly potent BCR-ABL1 inhibitor has shown superior efficacy compared to the existing tyrosine kinase inhibitor TKI in patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase ...
Hoch, Matthias, Sy, Sherwin, Lorenzo, Sebastien, Ho, Yu-Yun, Li, Ying Fei, Combes, Francois Pierre   +5 more
core   +1 more source

Optimizing Hydroxychloroquine Blood Levels and Long‐Term Hydroxychloroquine Intake Could Lower Atherosclerotic Cardiovascular Disease Risk and Prevent Polypharmacy in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is the cornerstone of systemic lupus erythematosus (SLE) management with benefits extending beyond SLE control, including protection against atherosclerotic cardiovascular disease (ASCVD). Although HCQ blood levels reflect recent exposure and long‐term intake reflects medication adherence, the impact of longitudinal ...
Shivani Garg, Murray Urowitz, Charlie Dentz, Niriti Adhikari, Fauzia Hollnagel, Nathalie Costedoat‐Chalumeau   +5 more
wiley   +1 more source

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults with Systemic Lupus Erythematosus

Arthritis Care &Research, Accepted Article.
Objective To characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE). Methods We analyzed cross‐sectional data from 451 adults in the Approaches to Positive, Patient‐centered Experiences of ...
Sarah L. Patterson, Russell Ellyson, Jessica Fitzpatrick, Ghizlane Yaakoubi, Bradley Pearce, S. Sam Lim, Jinoos Yazdany, Laura C. Plantinga   +7 more
wiley   +1 more source

Correction to: Pharmacokinetics of Nasal Esketamine in Patients with Allergic Rhinitis with and Without Nasal Decongestant Pretreatment and in Healthy Subjects with and Without Nasal Corticosteroid Pretreatment

, 2023
13291330Correction to: Clinical Pharmacokinetics https://doi.org/10.1007/s40262-023-01273 ...
Marc De Meulder, Solanki, Bhavna, Philipp Badorrek, Singh, Jaskaran, Jens M. Hohlfeld, Badorrek, Philipp, Peter Zannikos, Jaskaran Singh, Hohlfeld, Jens M., Bhavna Solanki, Meulder, Marc De, Zannikos, Peter   +11 more
core   +1 more source

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

Application of a new high performance liquid chromatography method to the pharmacokinetics of dibudipine in rats [PDF]

Purpose: To develop a HPLC method for assay of dibudipine in biological fluids and to study its pharmacokinetics in the rat. Methods. HPLC: 2 μl (20 μg/ml) mebudipine as internal standard, 0.2 ml NaOH 1 M and 2 ml ethyl acetate were added to 0.2 ml of ...
محمودیان, مسعود, غیائی, سعید, کیهانفر, فریبرز, بهلولی, شهاب   +3 more
core  

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients [PDF]

, 2006
Background: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible.
Mwenechanya, J, McIlleron Helen, Agbenyega, Tsiri, Molyneux, M, Olliaro, P, Miller, Raymond, Kyaw Win, Nosten Francois, Simpson, Julie A., Tembo, M, Simpson, Julie A, Ribeiro, Isabela, van Vugt, Michele, Weerasuriya, Kris, Molyneux Malcolm, Nicholas J White, Miller Raymond, Julie A Simpson, Pang, L, Pang, Lorrin, Gianni Di Perri, Simpson Julie A, White, Nicholas J., McIlleron, H, Francois Nosten, Mansor, Sharif, Perri, Gianni Di, Ward, Steve, Michele van Vugt, White, Nicholas J, Helen McIlleron, Ward Steve, Isabela Ribeiro, Sharif Mansor, Olliaro Piero, White Nicholas J, Simpson, JA, Perri, GD, Di Perri, Gianni, Di Perri, G, Piero Olliaro, Barnes, Karen I, Krudsood, S, Krishna, Sanjeev, Win, K, Navaratnam, Visweswaran, Barnes Karen I, White, NJ, van Vugt, M, Ward, S, Olliaro, Piero, Visweswaran Navaratnam, Navaratnam Visweswaran, Raymond Miller, James Mwenechanya, Molyneux, Malcolm, Sornchai Looareesuwan, Agbenyega, T, Krudsood, Srivicha, Agbenyega Tsiri, Folb, P, Mansor, S, Looareesuwan, S, van Vugt Michele, Looareesuwan, Sornchai, Perri Gianni Di, Tembo Madalitso, Lorrin Pang, Krudsood Srivicha, Gomes, M, Melba Gomes, Sanjeev Krishna, Julie A Simpson, Gomes, Melba, Win Kyaw, Navaratnam, V, Mansor Sharif, White, Nicholas, Folb Peter, Ribeiro Isabela, Madalitso Tembo, McIlleron, Helen, Weerasuriya Kris, Barnes, KI, Kris Weerasuriya, Pang Lorrin, Tembo, Madalitso, Folb, Peter, Malcolm Molyneux, Ribeiro, I, Srivicha Krudsood, Barnes, Karen I., Looareesuwan Sornchai, Mwenechanya, James, Gomes Melba, Krishna Sanjeev, Nosten, F, Tsiri Agbenyega, Karen I Barnes, Mwenechanya James, Steve Ward, Krishna, S, Peter Folb, Win, Kyaw, Weerasuriya, K, Miller, R, Nosten, Francois   +106 more
core   +2 more sources

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source