Results 21 to 30 of about 323,413 (255)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Pharmacokinetics of Psilocybin: A Systematic Review [PDF]

Background: Psilocybin has shown promise in therapeutic applications for mental disorders. Understanding the pharmacokinetics of psilocybin and its active metabolite psilocin is crucial for optimizing its clinical use and minimizing adverse effects ...
Perivolaris, Argyrios, Winkler, Olga, Loebenberg, Raimar, Lisa Burback, Burback, Lisa, Greenshaw, Andrew, Al-Shamali, Huda, Bhat, Venkat, Andrew Greenshaw, Trusha Tullu, Meshkat, Shakila, Olga Winkler, Amy C. Reichelt, Muhammad Ishrat Husain, Tullu, Trusha, Zhang, Yanbo, Jha, Manish K., Richard J. Zeifman, Jetly, Rakesh, Raimar Loebenberg, Husain, Muhammad Ishrat, Rakesh Jetly, Vermetten, Eric, Manish K. Jha, Shakila Meshkat, Argyrios Perivolaris, Eric Vermetten, Huda Al-Shamali, C. Reichelt, Amy, Yanbo Zhang, Zeifman, Richard J., Venkat Bhat   +31 more
core   +1 more source

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs [PDF]

, 2017
This review describes the pharmacokinetic properties of the systemically administered antileishmanial drugs pentavalent antimony, paromomycin, pentamidine, miltefosine and amphotericin B (AMB), including their absorption, distribution, metabolism and ...
Schellens, Jan H M, Dorlo, Thomas P. C.,, Kip, Anke E., Thomas P. C. Dorlo, Kip, Anke E, Schellens, Jan H. M., Beijnen, Jos H., Beijnen, Jos H.,, Schellens, Jan H. M.,, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Dorlo, Thomas P. C., Dorlo, Thomas P C, Anke E. Kip, Kip, Anke E.,, Jos H. Beijnen, Beijnen, Jos H, Jan H. M. Schellens   +17 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Overview of the European Medicines Agency's Development of Product-Specific Bioequivalence Guidelines [PDF]

, 2018
The authors thank the observers of the PKWP who have supported the development of the PSBGL and also Efthymios Manolis, Quirine Fillekes, and Milton Bonelli for constructive comments.
Jane O' Sullivan, Tomas Salmonson, Berntgen, Michael, Salmonson, Tomas, Kevin Blake, null null, Michael Berntgen, Blake, Kevin, Mifsud, Janet, Welink, Jan, Jan Welink, Pharmacokinetics Working Party, O'Sullivan, Jane   +12 more
core   +1 more source

Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases : A Systematic Review

, 2021
BACKGROUND: Patients affected by poverty-related infectious diseases (PRDs) are disproportionally affected by malnutrition. To optimize treatment of patients affected by PRDs, we aimed to assess the influence of malnutrition associated with PRDs on drug ...
Huitema, Alwin D R, Verrest, Luka, Wilthagen, Erica A, Dorlo, Thomas P C,, Beijnen, Jos H   +4 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source