Results 21 to 30 of about 240,659 (269)

A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis

Cell Death Discovery, 2022
As the modulation of serine/arginine-rich splicing factor 3 (SRSF3) may be therapeutically beneficial to colorectal cancer (CRC) treatment, the identification of novel SRSF3 inhibitors is highly anticipated. However, pharmaceutical agents targeting SRSF3
Yawen Zhang, Mengmeng Wang, Fanyi Meng, Man Yang, Yinshuang Chen, Xuqin Guo, Weiwei Wang, Yifan Zhu, Yundi Guo, Chunlai Feng, Shen Tian, Hongjian Zhang, Huanqiu Li, Jing Sun, Weipeng Wang   +14 more
doaj   +1 more source

Evaluation of the Pharmacokinetics of the Pancreastatin Inhibitor PSTi8 Peptide in Rats: Integration of In Vitro and In Vivo Findings

Molecules, 2022
PSTi8 is a pancreastatin inhibitory peptide that is effective in the treatment of diabetic models. This study investigates the pharmacokinetic (PK) properties of PSTi8 in Sprague Dawley rats, for the first time.
Guru R. Valicherla, Roshan A. Katekar, Shailesh Dadge, Mohammed Riyazuddin, Anees A. Syed, Sandeep K. Singh, Athar Husain, Muhammad Wahajuddin, Jiaur R. Gayen   +8 more
doaj   +1 more source

Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissues

mAbs, 2020
The decision to pursue a monoclonal antibody (mAb) as a therapeutic for disease intervention requires the assessment of many factors, such as target-biology, including the total target burden and its accessibility at the intended site of action, as well ...
Kip P. Conner, Cinthia V. Pastuskovas, Marcus Soto, Veena A. Thomas, Mylo Wagner, Dan A. Rock   +5 more
doaj   +1 more source

Fractal Pharmacokinetics [PDF]

Computational and Mathematical Methods in Medicine, 2009
Pharmacokinetics (PK) has been traditionally dealt with under the homogeneity assumption. However, biological systems are nowadays comprehensively understood as being inherently fractal. Specifically, the microenvironments where drug molecules interact with membrane interfaces, metabolic enzymes or pharmacological receptors, are unanimously recognized ...
openaire   +2 more sources

Impact of Erythrocyte Duffy Antigen Genetic Polymorphism on the Distribution of GroB-T, a Novel Human CXC Chemokine

Journal of Pharmacy & Pharmaceutical Sciences, 2007
Purpose. GroB-T, a human CXC chemokine, has been studied for its potential to mobilize stem cells. Chemokines bind specifically to receptors on target immune cells but also to a homologous erythrocyte blood group antigen, the Duffy Antigen/Receptor for ...
Timothy W Hepburn, LeeAnn P Tobia, Wei Shi, Timothy A McIntyre, Charles B Davis   +4 more
doaj   +1 more source

Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia

Pharmacology Research & Perspectives, 2019
MGS0274 besylate is an ester‐based lipophilic prodrug of a metabotropic glutamate (mGlu) 2 and mGlu3 receptor agonist MGS0008 and being developed for the treatment of schizophrenia.
Kohnosuke Kinoshita, Motoki Ochi, Katsuya Iwata, Misako Fukasawa, Jun‐ichi Yamaguchi   +4 more
doaj   +1 more source

Evaluation of dosing strategy for pembrolizumab for oncology indications

Journal for ImmunoTherapy of Cancer, 2017
Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
Tomoko Freshwater, Anna Kondic, Malidi Ahamadi, Claire H. Li, Rik de Greef, Dinesh de Alwis, Julie A. Stone   +6 more
doaj   +1 more source

Food intake attenuates the drug interaction between new quinolones and aluminum

Journal of Pharmaceutical Health Care and Sciences, 2018
Background Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted condition. However, the effect of food
Ayuko Imaoka, Kosuke Abiru, Takeshi Akiyoshi, Hisakazu Ohtani   +3 more
doaj   +1 more source

Systemic Evaluation on the Pharmacokinetics of Platinum-Based Anticancer Drugs From Animal to Cell Level: Based on Total Platinum and Intact Drugs

Frontiers in Pharmacology, 2020
Cisplatin, carboplatin, and oxaliplatin are the common platinum-based anticancer drugs widely used in the chemotherapeutic treatment of solid tumors in clinic.
Zhiying Qin, Guanghui Ren, Jinjie Yuan, Huili Chen, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen, Di Zhao   +8 more
doaj   +1 more source

Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection

Journal of Pharmaceutical Health Care and Sciences, 2023
Background Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species.
Daisuke Negishi, Okimichi Mitsumatsu, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu, Hiroshi Yamazaki   +5 more
doaj   +1 more source