Results 11 to 20 of about 323,413 (255)

Applications of human microdosing with accelerator mass spectrometry: assessment of ability to predict drug-drug interactions and determine the pharmacokinetics of enantiomers [PDF]

, 2012
In this thesis, new applications of microdosing were explored in two clinical trials. Methods were developed for the separation and quantification of 14C-labelled analytes in human plasma using two-dimensional HPLC and accelerator mass ...
Croft, M L
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The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine. [PDF]

, 2011
Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. This is an essential issue in cancer treatment due to its high toxicity. During the last decade, cyclin-dependent kinase
Hassan, Moustapha, Sallam, Hatem, Hassan, Zuzana   +2 more
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Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]

, 2010
The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Färnert, Anna, Zul Premji, Mårtensson, A, Annerberg, A, Mårtensson, Andreas, Annerberg, A., Andreas Mårtensson, Martensson, A., Bjorkman, A., Ngasala, B., Lindegårdh, N, Hietala, Sofia Friberg, Ngasala, B, Ashton, M., Dahlström, S, Gil, P, Friberg Hietala, Sofia,, Björkman, A, Premji, Z., Björkman, Anders, Sofia Friberg Hietala, Premji, Zul, Farnert, A., Dahlström, Sabina, Hietala, SF, Anna Annerberg, Annerberg, Anna, Anders Björkman, Anna Färnert, Pedro Gil, Lindegårdh, Niklas, Ashton, M, Ngasala, Billy, Michael Ashton, Färnert, A, Niklas Lindegårdh, Dahlstrom, S., Gil, P., Billy Ngasala, Lindegardh, N., Ashton, Michael, Gil, J. P., Premji, Z, Gil, Pedro, Hietala, S.F., Ashton, Michael,, Sabina Dahlström   +46 more
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Pharmacokinetics of torasemide and its metabolites in end-stage renal disease [PDF]

, 1994
The pharmacokinetics of torasemide, a new loop diuretic, as well as its active metabolites M1 and M3, and its inactive main metabolite, M5, were studied in 12 patients with end-stage renal failure during single i.v.
Schwab, A., Strutz, F., Müller, G. A., Krämer, Bernhard K., Braun, N., Risler, T.   +5 more
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The effects of pharmacogenetics on pharmacokinetics of artemisinin-based combinations in malaria patients [PDF]

, 2009
Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
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Normothermic machine perfused organs as models of drug pharmacokinetics and therapeutic delivery

, 2023
Less than 10% of drug candidates successfully pass through clinical trials and gain regulatory approval. One of the causes of translational failure is poor drug pharmacokinetics which are inadequately predicted by preclinical studies.
Clark, Tamsyn
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A systematic review on the pharmacokinetics of cannabidiol in humans [PDF]

, 2018
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient.
Stone, Nicole L., Andrew S. Yates, Yates, Andrew S., Sophie A. Millar, Nicole L. Stone, O 'Sullivan, Saoirse E., Millar, Sophie A., Saoirse E. O'Sullivan   +7 more
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Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-group Prospective Cohort Study in two sub-Saharan Africa Populations. [PDF]

, 2013
We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209)
Makonnen, Eyasu, Ngaimisi, E, Klaus-Dieter Riedel, Habtewold, A, Burhenne Juergen, Mugusi, F, Mugusi Sabina, Janabi, M, Omary Minzi, Mugusi Ferdinand, Getachew Aderaye, Makonnen, E, Mohammed Janabi, Yimer Getnet, Yimer, G, Eleni Aklillu, Habtewold Abiy, Minzi Omary, Minzi, O, Mugusi, S, Riedel Klaus-Dieter, Ngaimisi Eliford, Aderaye, G, Ferdinand Mugusi, Mugusi, Ferdinand, Abiy Habtewold, Habtewold, A., Aklillu Eleni, Wondwossen Amogne, Amogne, W, Ngaimisi, E.,, Ngaimisi, Eliford, Amogne Wondwossen, Aderaye, Getachew, Minzi, Omary, Aderaye Getachew, Bertilsso, L, Makonnen Eyasu, Habtewold, Abiy, Riedel, K, Eliford Ngaimisi, Bertilsson, Leif, Mugusi, Sabina, Amogne, W., Riedel, Klaus-Dieter, Makonnen, E., Juergen Burhenne, Yimer, Getnet, Aklillu, E, Amogne, Wondwossen, Bertilsson Leif, Burhenne, J, Leif Bertilsson, Eyasu Makonnen, Burhenne, Juergen, Mugusi, S., Janabi, Mohammed, Aklillu, Eleni, Janabi Mohammed, Bertilsson, L, Sabina Mugusi, Getnet Yimer, Minzi, O.   +62 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Trial of Systematic Education of Computer Sciences to Improve Comprehension of Pharmacokinetics [PDF]

, 2008
To improve students’comprehension of pharmacokinetics, we tried a systematic education of computer sciences with the aid of e-learning system. We reconstructed the curriculum to incorporate practical course using Microsoft Excel from first-year students,
西田, 孝洋, 丸田, 英徳, 鈴木, 斉, 和田, 光弘, 伊藤, 潔, 黒川, 不二雄   +5 more
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