Results 11 to 20 of about 239,934 (269)
The pharmacokinetics of amygdalin [PDF]
Archives of Toxicology, 1982 Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amygdalin have been investigated in the
Rauws, AG, Olling, M, Timmerman, A
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Pharmacokinetics and population pharmacokinetics in pediatric oncology [PDF]
Pediatric Blood & Cancer, 2019 AbstractPharmacokinetic research has become increasingly important in pediatric oncology as it can have direct clinical implications and is a crucial component in individualized medicine. Population pharmacokinetics has become a popular method especially in children, due to the potential for sparse sampling, flexible sampling times, computing of ...
Sebastiaan D.T. Sassen +3 more
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Fractal Pharmacokinetics [PDF]
Computational and Mathematical Methods in Medicine, 2009 Pharmacokinetics (PK) has been traditionally dealt with under the homogeneity assumption. However, biological systems are nowadays comprehensively understood as being inherently fractal. Specifically, the microenvironments where drug molecules interact with membrane interfaces, metabolic enzymes or pharmacological receptors, are unanimously recognized ...
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Cell Death Discovery, 2022 As the modulation of serine/arginine-rich splicing factor 3 (SRSF3) may be therapeutically beneficial to colorectal cancer (CRC) treatment, the identification of novel SRSF3 inhibitors is highly anticipated. However, pharmaceutical agents targeting SRSF3
Yawen Zhang +14 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2007 Purpose. GroB-T, a human CXC chemokine, has been studied for its potential to mobilize stem cells. Chemokines bind specifically to receptors on target immune cells but also to a homologous erythrocyte blood group antigen, the Duffy Antigen/Receptor for ...
Timothy W Hepburn +4 more
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Pharmacology Research & Perspectives, 2019 MGS0274 besylate is an ester‐based lipophilic prodrug of a metabotropic glutamate (mGlu) 2 and mGlu3 receptor agonist MGS0008 and being developed for the treatment of schizophrenia.
Kohnosuke Kinoshita +4 more
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Evaluation of dosing strategy for pembrolizumab for oncology indications
Journal for ImmunoTherapy of Cancer, 2017 Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
Tomoko Freshwater +6 more
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Frontiers in Pharmacology, 2020 Cisplatin, carboplatin, and oxaliplatin are the common platinum-based anticancer drugs widely used in the chemotherapeutic treatment of solid tumors in clinic.
Zhiying Qin +8 more
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Food intake attenuates the drug interaction between new quinolones and aluminum
Journal of Pharmaceutical Health Care and Sciences, 2018 Background Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted condition. However, the effect of food
Ayuko Imaoka +3 more
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Pharmaceutics, 2021 Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs).
Yiting Yang +5 more
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