Results 71 to 80 of about 586,923 (192)

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

Nature Communications, 2018
REV-ERBα is a nuclear receptor that links the circadian pathways with those of metabolism. Here the authors show REV-ERBα is also involved with linking the circadian system with the inflammatory pathways of an experimental model of colitis through ...
Shuai Wang, Yanke Lin, Xue Yuan, Feng Li, Lianxia Guo, Baojian Wu   +5 more
doaj   +1 more source

A comparison between the combined effect of calcium carbonate with sucroferric oxyhydroxide and other phosphate binders: an in vitro and in vivo experimental study

BMC Nephrology, 2019
Background Approximately 30% of patients on dialysis received combination therapy for their phosphate binder prescription; however, few studies for combined effects of phosphate binders are reported.
Atsushi Yaguchi, Kenji Akahane, Kumi Tsuchioka, Saori Yonekubo, Shota Yamamoto, Yasuaki Tamai, Satoshi Tatemichi, Hiroo Takeda   +7 more
doaj   +1 more source

Pharmacokinetic Studies with a Long-Acting sulfnamide in Subjects of Different Ages: A Modern Approach to Drug Dosage Problems in Developmental Pharmacology [PDF]

, 1968
F Sereni, L Perletti, Ettore Marubini, G Mars   +3 more
openalex   +1 more source

Pharmacokinetics of gamithromycin in pigs [PDF]

, 2012
Objectives : Gamithromycin, a 15-membered semi-synthetic macrolide antibiotic of the azalide subclass, has recently been developed for the treatment and prevention of bovine respiratory disease (BRD).
Croubels, Siska, De Backer, Patrick, De Baere, Siegrid, Meyer, Evelyne, Plessers, Elke, Watteyn, Anneleen, Wyns, Heidi   +6 more
core   +1 more source

Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis Subjects

Pharmaceutics
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically based pharmacokinetic (semi-PBPK) model to simultaneously predict the ...
Xin Luo, Zexin Zhang, Ruijing Mu, Guangyu Hu, Li Liu, Xiaodong Liu   +5 more
doaj   +1 more source

THE PHARMACOKINETICS OF PENAMECILLIN [PDF]

, 1966
M. Gibaldi, Morton A. Schwartz
openalex   +1 more source

In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. [PDF]

, 2018
BackgroundLiver disease (LD) prolongs mirtazapine half-life in humans, but it is unknown if this occurs in cats with LD and healthy cats.Hypothesis/objectivesTo determine pharmacokinetics of administered orally mirtazapine in vivo and in vitro (liver ...
Benson, Kellyi K, Fitzpatrick, Rikki L, Gustafson, Daniel L, Quimby, Jessica M, Ramirez, Dominique, Sieberg, Liberty G, Wittenburg, Luke A   +6 more
core  

Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Fluids and Barriers of the CNS
Background Chemotherapy-induced peripheral neuropathy (CIPN) represents a major unmet medical need that currently has no preventive and/or curative treatment.
Yang Hu, Milda Girdenyté, Lieke Roest, Iida Liukkonen, Maria Siskou, Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan   +7 more
doaj   +1 more source

The Aggravation of Clozapine-Induced Hepatotoxicity by Glycyrrhetinic Acid in Rats

Journal of Pharmacological Sciences, 2014
Clozapine (CLZ) was reported to be associated with hepatotoxicity. Glycyrrhetinic acid (GA) has a liver protective effect. Our preliminary experiments showed that GA aggravated rather than attenuated CLZ-induced hepatotoxicity in primary cultured rat ...
Ling-ling Jia, Ze-yu Zhong, Feng Li, Zhao-li Ling, Yang Chen, Wei-man Zhao, Ying Li, Shu-wen Jiang, Ping Xu, Yang Yang, Meng-yue Hu, Li Liu, Xiao-dong Liu   +12 more
doaj  

Evaluation of linear classifiers on articles containing pharmacokinetic evidence of drug-drug interactions

, 2012
Background. Drug-drug interaction (DDI) is a major cause of morbidity and mortality. [...] Biomedical literature mining can aid DDI research by extracting relevant DDI signals from either the published literature or large clinical databases.
Kolchinsky, Artemy, Li, Lang, Lourenço, Anália, Rocha, Luis M.   +3 more
core   +1 more source