Results 81 to 90 of about 219,082 (266)
Biomimetic Spider Silk by Crosslinking and Functionalization with Multiarm Polyethylene Glycol
Advanced Functional Materials, EarlyView.Bioconjugation of recombinant mini‐spidroins with multiarm polyethylene glycol (PEG) is employed to produce artificial spider silk, which can be crosslinked and chemically functionalized while maintaining a biomimetic spinning approach. The best fibers exhibit enhanced tensile strength and/or extensibility, both contributing to an increased toughness ...
Viktors Romaņuks +11 more
wiley +1 more source
Pharmaceutics, 2020 Oxaliplatin (L-OHP) is widely prescribed for treating gastroenterological cancer. L-OHP-induced peripheral neuropathy is a critical toxic effect that limits the dosage of L-OHP. An ideal chemotherapeutic strategy that does not result in severe peripheral
Shinji Kobuchi, Risa Shimizu, Yukako Ito
doaj +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2021 Patients with cardiovascular comorbidity are less tolerant to cardiotoxic drugs and should be treated with reduced doses to prevent cardiotoxicity. However, the safe‐equivalent dose of antitumor drugs in patients with cardiovascular disease/risk is ...
Lan Sang +7 more
doaj +1 more source
Population pharmacokinetics and dosing regimen optimization of tacrolimus in Chinese lung transplant recipients [PDF]
arXiv, 2020 We aimed to develop a population pharmacokinetic model of tacrolimus in Chinese lung transplant recipients, and propose model based dosing regimens for individualized treatment. We obtained 807 tacrolimus whole blood concentrations from 52 lung transplant patients and genotyped CYP3A5*3. Population pharmacokinetic analysis was performed using nonlinear
arxiv
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]
, 2014 To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel +10 more
core +1 more source
Advanced Functional Materials, EarlyView.Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng +12 more
wiley +1 more source
Extraction of Pharmacokinetic Evidence of Drug-drug Interactions from the Literature [PDF]
, 2014 Drug-drug interaction (DDI) is a major cause of morbidity and mortality and a subject of intense scientific interest. Biomedical literature mining can aid DDI research by extracting evidence for large numbers of potential interactions from published literature and clinical databases.
arxiv +1 more source
Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep [PDF]
, 2015 Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of
A., Di Salvo +6 more
core +1 more source
Bioresorbable and Wireless Rechargeable Implanted Na‐ion Battery for Temporary Medical Devices
Advanced Functional Materials, EarlyView.An all‐solid‐state bioresorbable Na‐ion battery is developed, composed entirely of bio‐eliminable materials. In vivo and ex vivo tests confirmed harmless disintegration of this implanted battery. Lifetime of the implanted battery can be precisely controlled by adjusting the dissolvable encapsulation layer's thickness.
Vedi Kuyil Azhagan Muniraj +8 more
wiley +1 more source
A comparative study of evaluating missing value imputation methods in label-free proteomics
Scientific Reports, 2021 The presence of missing values (MVs) in label-free quantitative proteomics greatly reduces the completeness of data. Imputation has been widely utilized to handle MVs, and selection of the proper method is critical for the accuracy and reliability of ...
Liang Jin +6 more
doaj +1 more source