Results 71 to 80 of about 9,387,370 (281)

Clinical Pharmacology in Old Persons

Scientifica, 2012
The epidemiological transition, with a rapid increase in the proportion in the global population aged over 65 years from 11% in 2010 to 22% in 2050 and 32% in 2100, represents a challenge for public health. More and more old persons have multimorbidities
Paul A. F. Jansen, Jacobus R. B. J. Brouwers   +1 more
doaj   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

CLINICAL PHARMACOLOGY OF DIURETICS

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2014
Clinical pharmacology of diuretics in the international system of ATC (anatomic-therapeutic-chemical) is presented. Classification of this group by the action mechanism and caused effects is provided.
I. V. Soldatenko
doaj  

Why clinical pharmacologists are needed?

Medwave, 2012
Drugs are one of the most widely used by doctors. The development of these as well as the impact that their; use only on benefits, risks or costs have determined the need for specialists in the area.
Andrea Giménez
doaj   +1 more source

Design, Implementation and Evaluation of Clinical Pharmacology Simulation Training Method for Nursing Students of Tehran School of Nursing and Midwifery

Journal of Medical Education and Development, 2021
Introduction: Educating students in a safe environment such as simulated centers can be effective in providing educational services and preparation for clinical work.
Amin Hosseini, Fatemeh Keshmiri, Zahra Rooddehghan, Zahra Mokhtari, Elahe Salamat gaznag, Fatemeh Bahramnezhad   +5 more
doaj  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Clinical pharmacology applications in clinical drug development and clinical care: A focus on Saudi Arabia

Saudi Pharmaceutical Journal, 2020
Drug development, from preclinical to clinical studies, is a lengthy and complex process. There is an increased interest in the Kingdom of Saudi Arabia (KSA) to promote innovation, research and local content including clinical trials (Phase I-IV ...
Abdullah Alsultan, Wael A. Alghamdi, Jahad Alghamdi, Abeer F. Alharbi, Abdullah Aljutayli, Ahmed Albassam, Omar Almazroo, Saeed Alqahtani   +7 more
doaj  

Basic & Clinical Pharmacology & Toxicology Policy for Experimental and Clinical studies.

Basic & Clinical Pharmacology & Toxicology, 2018
Inconsistencies in the reproducibility of research findings are of pertinent concern throughout the scientific community. Initially addressed in preclinical biomedicine studies [1, 2], the discussion has expanded to fields outside the natural sciences ...
P. Tveden-Nyborg, T. Bergmann, J. Lykkesfeldt   +2 more
semanticscholar   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source