Results 71 to 80 of about 444,964 (236)

Application progress of network pharmacology in the related research of diet therapy nursing

Huli yanjiu, 2022
Network pharmacology is a new subject based on the theory of systems biology，and has developed rapidly in recent years，especially in clinical and pharmacy applications.In this paper，on the basis of reading and sorting out previous studies related to ...
HAN Shifan, ZHU Ruifang, CHEN Yulu, CAO Yan, FENG Yaoqing, ZHANG Qian, CHEN Junxiang, ZHANG Jun   +7 more
doaj  

Editorial: Be positive about the negative in pharmacology: clinical studies in renal pharmacology 2022. [PDF]

Front Pharmacol, 2023
Prasad N, Yadav B.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Fenfluramine: A Review of Pharmacology, Clinical Efficacy, and Safety in Epilepsy. [PDF]

Children (Basel), 2022
Samanta D.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Velsecorat (AZD7594) Following Inhalation in Healthy Volunteers

Drug Design, Development and Therapy, 2022
Susanne Prothon,1 Magnus Aurivillius,2 Ulrika Tehler,3 Ulf G Eriksson,1 Ajay Aggarwal,4 Yingxue Chen5 1Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden; 2Late Stage ...
Prothon S, Aurivillius M, Tehler U, Eriksson UG, Aggarwal A, Chen Y   +5 more
doaj  

Bendamustine: A review of pharmacology, clinical use and immunological effects (Review). [PDF]

Oncol Rep, 2022
Lalic H, Aurer I, Batinic D, Visnjic D, Smoljo T, Babic A.   +5 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Ephedrae Herba: A Review of Its Phytochemistry, Pharmacology, Clinical Application, and Alkaloid Toxicity. [PDF]

Molecules, 2023
Tang S, Ren J, Kong L, Yan G, Liu C, Han Y, Sun H, Wang XJ.   +7 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source