Results 61 to 70 of about 898,450 (282)

Clinical Pharmacology in the UK, c.1950-2000: Industry and Regulation [PDF]

, 2008
Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.First published by the Wellcome Trust Centre for the ...
Reynolds, LA, Tansey, EM
core  

Process Improvement for Maximized Therapeutic Innovation Outcome. [PDF]

, 2017
Deconvoluting key biological mechanisms forms the framework for therapeutic discovery. Strategies that enable effective translation of those insights along the development and regulatory path ultimately drive validated clinical application in patients ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Clinical Pharmacology in Old Persons

Scientifica, 2012
The epidemiological transition, with a rapid increase in the proportion in the global population aged over 65 years from 11% in 2010 to 22% in 2050 and 32% in 2100, represents a challenge for public health. More and more old persons have multimorbidities
Paul A. F. Jansen, Jacobus R. B. J. Brouwers   +1 more
doaj   +1 more source

Filmed clinical cases improved communication skills of student of Pharmacology in Podiatry degree [PDF]

, 2015
Solving clinical case by writing-report lacks of students sympathies and interest in many cases. Make a short film is a novelty that really like to the students and may improve their arguing and planning capacities and their communication skills.
Bellido-Estevez, Inmaculada, Blanco-Reina, Encarnacion, De Pablo, Juan, García-Arnés, Juan Antonio, Gomez-Luque, Aurelio, Marquez, Elisa Isabel   +5 more
core  

The effect of weight, body mass index, age, sex, and race on plasma concentrations of subcutaneous sumatriptan: a pooled analysis. [PDF]

, 2016
Objective/backgroundFactors such as body size (weight and body mass index [BMI]), age, sex, and race might influence the clinical response to sumatriptan. We evaluated the impact of these covariates on the plasma concentration (Cp) profile of sumatriptan
Fisher, Dennis M, Gautam, Anirudh, Munjal, Sagar, Rapoport, Alan M   +3 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Establishing a clinical pharmacology fellowship program for physicians, pharmacists, and pharmacologists: a newly accredited interdisciplinary training program at the Ohio State University

Advances in Medical Education and Practice, 2014
Joseph P Kitzmiller,1,4 Mitch A Phelps,2 Marjorie V Neidecker,3 Glen Apseloff41Center for Pharmacogenomics, Colleges of Medicine and of Engineering, The Ohio State University Medical Center, 2Colleges of Pharmacy and Medicine, Pharmacoanalytic Shared ...
Kitzmiller JP, Phelps MA, Neidecker MV, Apseloff G   +3 more
doaj  

Scientific and pedagogical school of Professor A.A. Lebedev (commemorating the 95th anniversary of his birth)

Наука и инновации в медицине
August 28, 2025 marks the 95th anniversary of the birth of Aleksei A. Lebedev, the founder of the Samara Scientific and Pedagogical School of Pharmacologists, which has all-Russian and international recognition in the field of “Pharmacology of the ...
Aleksei V. Dubishchev, Elena N. Zaitceva, Elena V. Avdeeva   +2 more
doaj   +1 more source

Using Skeletal Outlines and Illustrative Diagrams as a Teaching/Learning Strategy in a Baccalaureate Nursing Pharmacology Course

Diversity of Research in Health Journal, 2017
Knowledge of pharmacology is an important aspect of safe, effective and competent clinical nursing practice, yet it can be challenging to teach. Many academics within the discipline of nursing are concerned that current nursing curricula may not be ...
Christina McMillan Boyles, Craig Duncan
doaj   +1 more source