Results 131 to 140 of about 2,320,535 (398)

The veterinary medicinal products market supply gap: A practical insight based on the Regulation (EU) 2019/6

Revista de Ciências Agroveterinárias
The Regulation (EU) 2019/6 establishes that the veterinary prescriptions should follow a cascade, according to their availability of the market. In sum, the veterinarian is authorized to use a medicine for human use only if there is no product available
Rafaela Nogueira, Catarina Jota Baptista, Lio Gonçalves, Ana Claúdia Coelho, Ana I. Faustino-Rocha, Marta Regueiro Purriños, José M. Gonzalo-Orden, Paula A. Oliveira   +7 more
doaj   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

CHEMICAL AND PHARMACOLOGICAL PROPERTIES OF THE POTENT, SLOW CONTRACTING SUBSTANCE (KININ) IN WASP VENOM [PDF]

, 1954
M Schachter, E. M. Thain
openalex   +1 more source

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Phytotherapy Research, 2016
Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum.
Xiaoxv Dong, Jing Fu, Xingbin Yin, Sali Cao, Xuechun Li, Longfei Lin, Jian Ni   +6 more
semanticscholar   +1 more source

Pharmacological Studies of d-Tubocurarine and Other Curare Fractions [PDF]

, 1948
G. M. Everett
openalex   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

System dynamics modelling in systems biology and applications in pharmacology [PDF]

, 2018
El modelado matemático de sistemas biológicos complejos es uno de los temas clave en la Biología de Sistemas y varios métodos computacionales basados ​​en la simulación computarizada han sido aplicados hasta ahora para determinar el comportamiento de los
Fernández, F. Javier, Fernández-de-Cañete-Rodríguez, Francisco Javier, Ramos Díaz, J. Carlos   +2 more
core  

Acidification of rat TRPV1 alters the kinetics of capsaicin responses

Molecular Pain, 2005
TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42°C.
Faltynek Connie R, Han Ping, Jarvis Michael F, Neelands Torben R, Surowy Carol S   +4 more
doaj   +1 more source