Results 61 to 70 of about 1,473,821 (310)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Effects of Clinical Pharmacology Training on Prescription Writing Skills of Interns [PDF]
, 2013 Introduction: The skill of appropriate prescription writing is a corner stone of treatment. Due to this fact, we designed a study for evaluating interns prescription writing skills after clinical pharmacology training.
Hamid Noshad, Parviz Saleh
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
HIV-1 Protease Inhibitors From Marine Brown Alga: A Literature Review [PDF]
, 2017 The human immunodeficiency virus type 1 (HIV-1) causes an infectious disease that if left untreated can progress to acquired immunodeficiency syndrome (AIDS) and be fatal.
Nunez Aguilar, Eric
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Oléagineux, Corps gras, Lipides, 2004 Lipid chemistry is the main know-how of the research and development Center of Laboratoires Expanscience. Our paper will be focused on this field with special emphasize on three different techniques molecular distillation, bio-enzymatic reaction and ...
Piccardi Nathalie +6 more
doaj +1 more source
Molecules, 2016 Hedyotis diffusa Willd (H. diffusa) is a well-known Chinese medicine with a variety of activities, especially its anti-cancer effect in the clinic. Up to now, 171 compounds have been reported from H.
Rui Chen +4 more
doaj +1 more source
, 2017 Pharmacology is the science about interaction between drugs and human organism. Pharmacology is divided into general and special pharmacology. General pharmacology studies the general laws of drug interaction with human organism.
Kachanova, Alla Anatoliivna +8 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source